LATEST UPDATES » Vol 23, No 04, April 2019 – Career development for researchers       » CRISPR not as precise as thought       » Insomnia spreads among young Chinese       » Chinese HEV vaccine begin clinical trial in U.S       » Eating mushrooms may reduce risk of cognitive decline       » Green tea cuts obesity in mice      
New discovery reveals acne, acne scarring and osteoporosis may be related to collagen issues
Researchers study rare genetic disease called Winchester syndrome which causes severe acne, bad scarring and osteoporosis, and hope their discovery will pave the way for better acne treatments.

Acne vulgaris (acne) is the most common skin disease in the world.1 In developed countries such as Singapore, it can affect up to 80 to 90 per ceent of adolescents. Usually, the disease goes away by itself. But for many patients, acne can persist into adulthood and leave disfiguring scars, estimated to affect up to 95 per cent of patients.2 The resulting disfigurement can lead to anxiety, reduced self-esteem and, in extreme cases, depression or thoughts of suicide.3

Researchers from Agency for Science, Technology and Research鈥檚 (A*STAR) Institute of Medical Biology (IMB) in Singapore, together with colleagues from other institutes across Singapore, Europe and Australia, have discovered that acne as well as the associated scarring can result from connective tissue problems.

The starting point was to study a rare genetic disease called Winchester syndrome, which causes severe acne, bad scarring and osteoporosis. Understanding the role of genes in rare diseases can help boost understanding of common diseases. In this case, IMB Research Director, Prof Maurice Van Steensel鈥檚 team discovered that the symptoms arising from Winchester syndrome are all due to issues with an inability of cells to digest the collagen that is around them. Collagen is the protein that makes up most of the connective tissue in the skin and is also essential for bones.

The researchers then made a zebrafish model of Winchester syndrome so they are able to develop and test new drugs that may help people with acne, scars, or osteoporosis. The scientists expect to translate this new understanding into practical development of treatments soon. Their research will also direct efforts towards understanding how defective tissue remodelling relates to acne, and how it can be manipulated for therapeutic benefit.

Click here for the complete issue.

news Which country has the worst sleepers
news Asia is the fastest growing region for nutraceuticals
news 2018 Nobel Prize in Physiology or Medicine winners
news Vitafoods Asia expands by 40 per cent in 2018
Asia Pacific Biotech News

APBN Editorial Calendar 2019
Taiwan Medical tourism
Marijuana as medicine — Legal marijuana will open up scientific research
Driven by curiosity
Career developments for researchers
Editorial calendar is subjected to changes.
About Us
Available issues
Editorial Board
Letters to Editor
Instructions to Authors
Advertise with Us
World Scientific Publishing Co. Pte. Ltd.
5 Toh Tuck Link, Singapore 596224
Tel: 65-6466-5775
Fax: 65-6467-7667
» For Editorial Enquiries:
   biotech_edit@wspc.com or Ms Lim Guan Yu
» For Subscriptions, Advertisements &
   Media Partnerships Enquiries:
Copyright© 2019 World Scientific Publishing Co Pte Ltd  •  Privacy Policy