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LATEST UPDATES » Vol 22, No 10, October 2018 – Next-generation biosensors - Transforming the delivery of healthcare       » China tops world in alcohol-related deaths       » First China-developed drug for colorectal cancer approved in China       » World's first shrimp genome may reveal why females are superior       » Tetris-like program could speed breast cancer detection       » Wearable patch to monitor blood pressure inside body      
EYE ON CHINA
Oncologists suggest new therapy by freezing cancer cells
Compound found that could potentially stop cancer cells from moving around the body

In a study published in Nature Communications, it was revealed that a novel approach can halt the movement of cancer cells before they spread throughout the body.

Raymond Bergan, professor of medicine at Oregon Health & Science University (OHSU) said that the majority of cancer treatment therapies were directed toward killing cancer but no one had developed a therapy that can stop cancer cells from moving around the body.

The study outlined a multidisciplinary team's work with KBU2046, a compound that was found to inhibit cell motility in four different human cell models of solid cancer types: breast, prostate, colon and lung cancers.

"Movement is key: the difference is black and white, night and day. If cancer cells spread throughout your body, they will take your life. We can treat it, but it will take your life," said Bergan.

Chemists led by Karl Scheidt, professor of chemistry at Northwestern University designed and created new molecules and Bergan's team evaluated them for their ability to inhibit cell motility.

Using chemical synthesis approaches, Scheidt and team accessed new compounds that minimized motility in tumor cells, with few side effects and very low toxicity.

"We started off with a chemical that stopped cells from moving, then we increasingly refined that chemical until it did a perfect job of stopping the cells with no side effects," said Bergan.

Bergan said the key to this drug was engaging the heat shock proteins or the "cleaners" of a cell. "The way the drug works is that it binds to these cleaner proteins to stop cell movement, but it has no other effect on those proteins."

The team of investigators includes Bergan's team at OHSU, a chemist from Northwestern University as well as researchers from Xiamen University in China, the University of Chicago, and the University of Washington.

"Our eventual goal is to be able to say to a woman with breast cancer: here, take this pill and your cancer won't spread throughout your body. The same thing for patients with prostate, lung, and colon cancer," Bergan said.

Source: Xinhua

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PR NEWSWIRE  
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EDITORS' CHOICE  
COLUMNS  

APBN Editorial Calendar 2018
January:
Obesity / Outlook for 2018
February:
Searching for the fountain of youth
March:
Women in Science - Making a difference
April:
Digestive health in the 21st century - Trust your guts
May:
Dental health - The root to good health
June:
Cancer - Therapies and strategies for better patient outcomes
July:
Water management - Technologies for biotech and pharmaceutical industries
August:
Regenerative technology - Meat of the future
September:
Doctor Robot - The digital healthcare revolution
October:
Bones / Breast cancer
November:
Liver health / Top science research nations & institutions
December:
AIDS / Breakthrough of the year/Emerging trends
Editorial calendar is subjected to changes.
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