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Dietary supplement can potentially treat HER2 positive breast cancer
Mayo Clinic researchers discovered that cyclocreatine, a dietary supplement used in sports drinks, may block the growth of HER2 positive breast cancer

Researchers at Mayo Clinic, USA, have identified an important new pathway by which HER2 positive breast cancers grow and have discovered that a dietary supplement called cyclocreatine may block the growth of HER2 positive breast cancer. Their findings were published in Cell Metabolism.

“The HER2 receptor tyrosine kinase, which functions as an ‘on’ or ‘off’ switch in cellular functions, is a key driver of breast cancer, and is overexpressed in about a quarter of all breast cancers,” says Dr Taro Hitosugi, a pharmacologist at Mayo Clinic and corresponding author of the paper. “While drugs such as trastuzumab improved outcomes for some patients with HER2 positive breast cancer, some tumours are or may become resistant to this drug.”

Dr Hitosugi and his colleagues developed a treatment to target tumour mitochondrial energy metabolism, which is the process cancer cells use to manipulate energy during cell metabolism in order to grow.

The challenge was to determine which mitochondrial enzymes were activated by HER2 cancer cells. “We employed metabolomics and proteomics approaches to identify HER2-dependent metabolic events, and discovered that HER2 signaling activates mitochondrial creatine kinase 1,” says Dr Hitosugi.

Dr Hitosugi and his colleagues discovered that cyclocreatine, a dietary supplement used in sports drinks, effectively targets mitochondrial creatine kinase 1 enzyme and reduces cancer growth without toxicity. This finding was confirmed in mice models where a patient-derived, trastuzumab-resistant HER2 positive tumours were administered to the mice.

Future clinical trials will be needed to determine the effectiveness of this drug for HER2 positive breast cancer resistant to standard therapies.”

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APBN Editorial Calendar 2018
January:
Obesity / Outlook for 2018
February:
Searching for the fountain of youth
March:
Women in Science - Making a difference
April:
Digestive health in the 21st century - Trust your guts
May:
Dental health - The root to good health
June:
Cancer - Therapies and strategies for better patient outcomes
July:
Water management - Technologies for biotech and pharmaceutical industries
August:
Regenerative technology - Meat of the future
September:
Doctor Robot - The digital healthcare revolution
October:
Bones / Breast cancer
November:
Liver health / Top science research nations & institutions
December:
AIDS / Breakthrough of the year/Emerging trends
Editorial calendar is subjected to changes.
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