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LATEST UPDATES » Vol 23, No 06, June 2019 – Clinical trials — What's in a name?       » Study reveals mechanism behind ginger's warming effect on body       » China proposes major changes to pharmaceutical regulations       » Six plants native to Southeast Asia are promising cancer warriors       » Cancer cells are addicted to methionine       » World's first molecular swing      
INSIDE INDUSTRY
GSK to buy oncology drugmaker Tesaro for US$5.1 billion
Helps accelerate GSK鈥檚 pipeline and commercial capability in oncology

GlaxoSmithKline plc (GSK) has announced it will acquire Tesaro, an oncology-focused company based in Waltham, Massachusetts, for US$5.1 billion.

The proposed transaction will significantly strengthen GSK's pharmaceutical business, accelerating the build of GSK's pipeline and commercial capability in oncology.

The deal gives GSK a major marketed product, Zejula (niraparib), an oral poly ADP ribose polymerase (PARP) inhibitor currently approved for use in ovarian cancer. Zejula is currently approved in the U.S. and Europe as a treatment for adult patients with recurrent ovarian cancer who are in response to platinum-based chemotherapy, regardless of BRCA mutation or biomarker status.

PARP inhibitors are transforming the treatment of ovarian cancer, notably demonstrating marked clinical benefit in patients with and without germline mutations in a BRCA gene (gBRCA).

GSK also believes PARP inhibitors offer significant opportunities for use in the treatment of multiple cancer types. In addition to ovarian cancer, Zejula is currently being investigated for use as a possible treatment in lung, breast and prostate cancer, both as a monotherapy and in combination with other medicines, including with Tesaro's own anti-PD-1 antibody (dostarlimab, formerly known as TSR-042).

In addition to Zejula, Tesaro has several oncology assets in its pipeline including antibodies directed against PD-1, TIM-3 and LAG-3 targets.

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EDITORS' CHOICE  
COLUMNS  

APBN Editorial Calendar 2019
January:
Taiwan Medical tourism
February:
Marijuana as medicine — Legal marijuana will open up scientific research
March:
Driven by curiosity
April:
Career developments for researchers
May:
What's cracking — Antibodies in ostrich eggs
June:
Clinical trials — What's in a name?
Editorial calendar is subjected to changes.
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