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EYE ON CHINA
Faster and cheaper manufacturing of CAR-T production
Gracell Biotechnologies developes FasT CAR-T, a breakthrough technology for hematological malignancies

Gracell Biotechnologies, a China-based immune cell gene therapy company has developed a faster and cheaper way of manufacturing CAR-T treatments.

FasT CAR-T, a revolutionary platform shortens the manufacturing time of CAR-T treatments from two weeks to one day.

FasT CAR-T also lowers manufacturing costs to a fraction of previous CAR-T therapies, while showing higher potency of CD19-directed FasT CAR-T ("CD19-F-CAR-T") in B-Cell acute lymphoblastic leukemia (B-ALL) and non-Hodgkin Lymphoma (NHL), both in vitro and in vivo.

With a first-in-human clinical study of CD19-F-CAR-T ongoing, Gracell said early clinical results show the therapy is safe and significantly more potent (20-40 times) than conventionally manufactured CAR-T agents (C-CAR-T) for treating B-ALL.

FasT CAR-T requires only one day for manufacturing (not including seven days for releasing tests per regulatory requirement), while C-CAR-T manufacturing takes about two weeks and another seven days for testing. Hence, FasT CAR-T reduces vein-to-vein time by an average of 12 days, which is critical for patients with rapidly progressing disease.

Source : Gracell Biotechnologies

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EDITORS' CHOICE  
COLUMNS  

APBN Editorial Calendar 2019
January:
Taiwan Medical tourism
February:
Marijuana as medicine — Legal marijuana will open up scientific research
March:
Driven by curiosity
April:
Career developments for researchers
May:
What's cracking — Antibodies in ostrich eggs
Editorial calendar is subjected to changes.
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