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Development of artificial intelligence (AI) tools and analytics platforms for improving cell therapy and immuno-oncology
Proteona Pte. Ltd. has announced its participation in AI Singapore’s 100 Experiments (100E) programme to develop AI tools for single cell multi-omics data analysis.

Proteona and AI Singapore partner to improve cell therapies and immuno-oncology treatments through single cell analysis of tumours and CAR T cells. The project is being conducted in collaboration with Prof Wong Lim Soon, Kwan Im Thong Hood Cho Temple Chair Professor from the National University of Singapore (NUS) School of Computing, a leading expert in bioinformatics and computational biology. Together with Proteona bioinformaticians and data scientists, the team aims to solve key challenges in single cell data analysis using AI tools.

A key obstacle of single cell data analysis is combining datasets from different sources such as different patient samples and obtaining robust cell clustering and cell-type annotation. Single cell analysis often leads to the discovery of novel cell populations with features that had not been previously observed. Clinical samples, such as tumor biopsies, are known to be very heterogeneous, making cell type identification very challenging. Moreover, single-cell analysis is prone to noise and batch-effects that make comparisons across experiments difficult.

As a result of these challenges, cell clustering and cell annotation usually requires extensive manual intervention. This is time consuming, requires specialized knowledge and expertise, and is prone to human error and bias.

“Batch effects are prevalent in -omics data. This is particularly pronounced in single-cell measurements. Profiles from one batch are not directly compatible with that from another batch.” says Prof Limsoon Wong, NUS School of Computing. “The AI-driven components here will facilitate a more convenient and explicit identification of the specific protein complexes and biological circuits relevant to cell-types and states.”

With this collaboration, the team will further develop their robust computational workflows for knowledge-driven analysis, with an AI-based system trained using Proteona’s in-house annotated datasets. Proteona’s ESCAPE™ RNA-Seq technology and services simultaneously measures both proteomic and transcriptional expression at single-cell resolution. The developed AI-analysis will leverage this unique modality to enable deeper insights into single-cell biology.

“An immediate outcome of this collaboration will be a tool to improve the quality of results presented to our customers. It will save them time in annotating known cell types and correcting for batch effects. This platform is also used internally as a way for building our database of cell types and cell states which is then used for better annotating our customer’s data. We will also use these tools for our internal programs in biomarker discovery and diagnostic development,” says Dr Andreas Schmidt, CEO of Proteona.

“We see the merging of biotechnology and data-driven IT as one of the biggest value drivers in the health industry. With Proteona`s single cell proteogenomic data platform the company is in a unique position to impact health decisions for therapy development and the clinic,” explains Chou Fang Soong, General Partner Pix Vine Capital, one of Proteona´s investors.

With founders Prof Gene Yeo of UCSD, Prof Jonathan Scolnick of NUS and Deputy Director of the Molecular Engineering Laboratory, A*STAR, Dr Shawn Hoon, Proteona has strong roots in cutting edge academic discoveries around the world. The Proteona - AI Singapore consortium actively seeks additional partners from the cell therapy and hematology-oncology communities to contribute to their international single cell analysis initiative.

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NEWS CRUNCH  
news The Proteona Oncology Challenge using ESCAPETM Single Cell Proteogenomic Analysis
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news Medial Fair Thailand opened on 11th September 2019 with a focus on future-proofing Thailand's healthcare industry to meet the challenges and opportunities of the next decade
news Biofuel Producers and Users to Convene in Singapore for Global Biofuels Summit
PR NEWSWIRE  
Asia Pacific Biotech News
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LIFE OF A SCIENTIST  

APBN Editorial Calendar 2019
January:
Taiwan Medical tourism
February:
Marijuana as medicine — Legal marijuana will open up scientific research
March:
Driven by curiosity
April:
Career developments for researchers
May:
What's cracking — Antibodies in ostrich eggs
June:
Clinical trials — What's in a name?
July:
Traditional Chinese medicine in modern healthcare — Integrating both worlds
August:
Digitalization vs Digitization — Exploring Emerging Trends in Healthcare
September:
Healthy Ageing — How Science is chipping in
October:
Disruptive Urban Farming — Microbes, Plasmids, and Recycling
Editorial calendar is subjected to changes.
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