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NEWS CRUNCH
Lilly's Ramucirumab (Cyramza®) Is Now Available in Singapore
First country in ASEAN to approve the new biologic therapy that extends survival in patients with advanced stomach cancer after prior chemotherapy

SINGAPORE, 13 December 2016 - CYRAMZA® (ramucirumab) is now available to Singaporeans living with advanced gastric cancer. The drug gained approval by Singapore's Health Science's Authority (HSA) earlier this year, marking the first (1st) regulatory approval in ASEAN. CYRAMZA is already available to patients in Japan, Korea, Taiwan and Hong Kong.

Gastric cancer, frequently referred to as stomach cancer, is the fifth most common cancer in the world and the third-leading cause of cancer-related deaths. There were nearly one million new cases worldwide in 2012 (631,000 men, 320,000 women), with approximately 723,000 deaths (469,000 men, 254,000 women). [1] In Singapore, stomach cancer ranks among the top ten most frequent cancers detected in the country in both men and women [2]. According to Dr Matthew Ng, Senior Consultant, Division of Medical Oncology, National Cancer Centre Singapore, "The local registry estimated that during the period of 2010-2014, there were a total number of 2,547 new cases of stomach cancer and a total of 1,580 cancer deaths due to gastric cancer were reported- representing a high mortality rate. Stomach cancer was also found to be the 4th most common cause of cancer deaths in males and 5th most common cause of cancer deaths in females in Singapore." [2]

CYRAMZA® (ramucirumab) is a new biologic agent to show improved overall survival and progression-free survival as a single agent or in combination with paclitaxel chemotherapy in patients with advanced gastric cancer that has progressed after initial treatment - a devastating disease that is difficult to treat and for which the prognosis for patients has been poor.

CYRAMZA® marketing authorization approval by HSA was based on results from two global, randomised, double-blinded and placebo-controlled Phase III studies: RAINBOW and REGARD. RAINBOW evaluated CYRAMZA® in combination with paclitaxel (a type of chemotherapy) for advanced gastric or gastro-oesophageal junction adenocarcinoma after prior chemotherapy while REGARD evaluated CYRAMZA® as a single agent in the same setting. [3,4]

Dr Yong Wei Peng, Associate Director (Research) and Senior Consultant from the Department of Haematology-Oncology, National University Cancer Institute, Singapore (NCIS) explains, "What makes stomach cancer one of the most challenging diseases to treat is that patients often come to us at advanced stages where treatment options are limited. In the second-line setting, chemotherapy significantly improved the overall survival compared with best supportive care; However, the median survival with chemotherapy alone has been less than 6 months. [5,6,7] As per the RAINBOW study, CYRAMZA® used in combination with chemotherapy to treat patients who have failed prior treatment, significantly improved response rate, duration of disease control and survival when compared to chemotherapy alone." [3]

Dr Faiz Ansari, General Manager for Lilly Singapore, Malaysia, Indonesia and Brunei says that he is proud to be a part of this meaningful moment for the Singapore oncology field. "For more than fifty years, Lilly has been dedicated to delivering life-changing medicines and support to people living with cancer and those who care for them. Today, we are building on our commitment and marking an important milestone as we bring a new biologic agent, CYRAMZA® for the treatment of advanced stomach cancer to Singapore ahead of many other countries within the region. We hope CYRAMZA® will make a difference to the patients, their caregivers and doctors who are fighting this debilitating disease," said Dr Ansari.

References:

  1. Globocan 2012 Cancer Fact Sheet. Stomach cancer estimated incidence, mortality and prevalence worldwide in 2012. https://globocan.iarc.fr/Pages/fact_sheets_cancer.aspx. (Accessed December 1, 2014).
  2. Singapore Cancer Registry Report (2010-2014) released by National Registry of Diseases Office (NRDO, 2015).
  3. Wilke et al, Ramucirumab plus paclitaxel versus placebo plus paclitaxel in patients with previously treated advanced gastric or gastro-oesophageal junction adenocarcinoma (RAINBOW): a double-blind, randomised phase 3 trial. Lancet 2014. Published online September 18, 2014 https://dx.doi.org/10.1016/S1470-2045(14)70420-6.
  4. Fuchs et al, Ramucirumab Monotherapy For Previously Treated Advanced Gastric Or Gastro-Oesophageal Junction Adenocarcinoma (REGARD): An International, Randomised, Multicentre,Placebo-Controlled, Phase 3 Trial. Lancet. 2013 Published online October 3, 2013 https://dx.doi.org/10.1016 /S0140-6736(13)61719-5
  5. Kang et al. Salvage chemotherapy for pretreated gastric cancer: a randomized phase III trial comparing chemotherapy plus best supportive care with best supportive care alone. J Clin Oncol 2012; 30: 1513-18.
  6. Ford et al, on behalf of the COUGAR-02 Investigators. Docetaxel versus active symptom control for refractory oesophagogastric adenocarcinoma (COUGAR-02): an open-label, phase 3 randomised controlled trial. Lancet Oncol 2014; 15: 78-86
  7. Thuss-Patience PC et al. Survival advantage for irinotecan versus best supportive care as second-line chemotherapy in gastric cancer--a randomised phase III study of the Arbeitsgemeinschaft Internistische Onkologie (AIO). Eur J Cancer 2011; 47: 2306-14.

About Eli Lilly and Company
Lilly is a global healthcare leader that unites caring with discovery to make life better for people around the world. We were founded more than a century ago by a man committed to creating high-quality medicines that meet real needs, and today we remain true to that mission in all our work. Across the globe, Lilly employees work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to communities through philanthropy and volunteerism.

For more than fifty years, Lilly has been dedicated to delivering life-changing medicines and support to people living with cancer and those who care for them. Lilly is determined to build on this heritage and continue making life better for all those affected by cancer around the world.

About Eli Lilly (Singapore) Pte Ltd
Eli Lilly (Singapore) Pte Ltd was established in 1994 with a team of committed, diverse and talented people inspired and guided by Lilly's heritage, mission and values of Integrity, Respect and Excellence to serve the Singapore community.

We are driven and committed to make life better for people in Singapore through a broad portfolio of medicines and support programs in the field of diabetes, oncology, men's health, osteoporosis and mental health.

Lilly Singapore believes in working in partnerships with the different stakeholders in the healthcare field to advance the understanding and management of chronic diseases such as diabetes, cancer and

auto-immune diseases. In 1997, Lilly established Lilly-NUS (LNUS) partnership with the National University of Singapore and the National Science and Technology Board, to expand its R&D programs. Today this R&D center, one the six centers around the world for Lilly, is leveraging the science and research talent and expertise in Singapore to discover and deliver meaningful solutions that address the unmet need of patients living in Singapore.

To learn more about Lilly Singapore, please visit us at www.lilly.com.sg.

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APBN Editorial Calendar 2018
January:
Obesity / Outlook for 2018
February:
Searching for the fountain of youth
March:
Women in Science - Making a difference
April:
Digestive health in the 21st century - Trust your guts
May:
Dental health - The root to good health
June:
Oncology / Biotech landscape in APAC
July:
Water management / Vaccination
August:
Regenerative medicine / Biotech start ups
September:
Digital healthcare / 3D printing
October:
Bones / Breast cancer
November:
Liver health / Top science research nations & institutions
December:
AIDS / Breakthrough of the year/Emerging trends
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