LATEST UPDATES » Vol 22, No 03, March 2018 – Women in Science - Making a difference       » Brain aging in ASEAN       » Chinese scientists find antidote to centipede venom       » Measuring the risks and rewards of drug development       » Ketone drink could help diabetics by lowering blood sugar       » What value-based healthcare means for Asia       » Improve healthcare access to tackle Asia's healthcare challenge      
AdAlta pioneers novel drug for rare lung disease
Compelling new lung disease treatment pioneered in Victoria gains global attention alongside top researchers and drug developers.

A novel drug treatment emerging from Victoria for the serious lung condition idiopathic pulmonary fibrosis will be spotlighted among world-leading researchers and scientists at the global IPF Summit in Boston from 21 to 23 August 2017.

Idiopathic pulmonary fibrosis (IPF) is a fibrotic lung condition that causes persistent and progressive scarring of the tiny air sacs (alveoli) in the lungs, with symptoms including shortness of breath and coughing1. Lung Foundation Australia estimate that there are around 2,300 new cases diagnosed in in Australia every year2. The prognosis of IPF is very poor, with a median survival of only three to five years after diagnosis.3

The new drug, AD-114, is being developed by the Australian biotech AdAlta (ASX:1AD), using AdAlta's proprietary 'i-body' technology. A phase 1 clinical trial will start next year.

AD-114 differs from existing treatment options and others currently in clinical development due to its unique mode of action that targets the GPCR chemokine receptor CXCR4. AD-114 has been demonstrated to have both anti-inflammatory and anti-fibrotic activity, hitting a sweet spot for a potential therapy for IPF.

The effects of AD-114 have been described by world-leading lung disease researcher Professor Cory Hogaboam (Cedars Sinai Medical Centre) as "impressive" and "providing a compelling case" for treating IPF.

AdAlta CEO, Sam Cobb, has been invited to speak at the inaugural summit to showcase the novel therapeutic approach to this largely under-treated area. Ms Cobb will represent the only Australian company in the line-up of academics, international biotech and pharma speakers that include Prof Hogaboam as well as speakers from Genentech, Bristol-Myers Squibb, Celgene and Medimmune.

"IPF is a disease with high unmet clinical need and we do believe AD-114 will provide the clinical community and patients with a much-needed new treatment option," Ms Cobb said.

"Although our focus with AD-114 is IPF, AD-114 has the potential to treat a wide-range of fibrotic conditions including wet age-related macular degeneration, of which there are 21,000 new cases diagnosed in Australia each year4 and non-alcoholic fatty liver disease, which affects around 5.5 million Australians and is a precursor to nonalcoholic steatohepatitis (NASH)5.

"That we've been invited to speak alongside world experts at the inaugural IPF Summit is immensely validating of the critical nature of our work."

AD-114 has received orphan drug status by the FDA, and if approved would be a first-in-class treatment. 'Orphan' drugs are those developed to treat a rare medical condition, and they are usually granted accelerated development and regulatory timelines.


  1. Lung Foundation Australia [online] at https://lungfoundation.com.au/health-professionals/idiopathic-pulmonary-fibrosis-registry/ [accessed 3 August 2017]
  2. Lung Foundation Australia [online] at https://lungfoundation.com.au/patient-support/rarelung/idiopathic-pulmonary-fibrosis-ipf/ [accessed 3 August 2017]
  3. ATS, 2000; Raghu et al., 2011
  4. Macular Degeneration Foundation [online] at https://www.mdfoundation.com.au/sites/default/files/MDBooklet_2017-04_WEB.pdf [accessed 7 August 2017]
  5. The Economic Cost and Health Burden of Liver Disease in Australia (Jan 2013), Gastroenterological Society of Australia)
news Shire, Microsoft and EURORDIS form Global Commission to accelerate time to diagnosis for children with rare diseases
news EmTech Asia explores future of life, humanity and economy
news Biology of Ageing II - Impactful Interventions
Asia Pacific Biotech News

Lady Ganga: Nilza'S Story
Subscribe to APBN E-Newsletter
Find us under 'Others' option to receive APBN e-newsletters thrice a month!

APBN Editorial Calendar 2018
Obesity / Outlook for 2018
Searching for the fountain of youth
Women in Science - Making a difference
Digestive health / Intellectual property
Asthma / Dental health
Oncology / Biotech landscape in APAC
Water management / Vaccination
Regenerative medicine / Biotech start ups
Digital healthcare / 3D printing
Bones / Breast cancer
Liver health / Top science research nations & institutions
AIDS / Breakthrough of the year/Emerging trends
Editorial calendar is subjected to changes.
About Us
Available issues
Editorial Board
Letters to Editor
Instructions to Authors
Advertise with Us
World Scientific Publishing Co. Pte. Ltd.
5 Toh Tuck Link, Singapore 596224
Tel: 65-6466-5775
Fax: 65-6467-7667
» For Editorial Enquiries:
   biotech_edit@wspc.com or Ms Lim Guan Yu
» For Subscriptions, Advertisements &
   Media Partnerships Enquiries:
Copyright© 2018 World Scientific Publishing Co Pte Ltd  •  Privacy Policy