4. Paul L. Modrich
Affiliation: Howard Hughes Medical Institute, Durham, NC, USA, Duke University School of Medicine, Durham, NC, USA
Prize Motivation: "for mechanistic studies of DNA repair"
Modrich demonstrated how the cell corrects errors that occur when DNA is replicated during cell division. This mechanism, known as 'mismatch repair', reduces the error frequency during DNA replication by about a thousand fold.
5. Tomas Lindahl
Affiliation: Francis Crick Institute, Hertfordshire, United Kingdom, Clare Hall Laboratory, Hertfordshire, United Kingdom
Prize Motivation: "for mechanistic studies of DNA repair"
Lindahl demonstrated that DNA decays at a rate that ought to have made the development of life on Earth impossible.
6. Aziz Sancar
Affiliation: University of North Carolina, Chapel Hill, NC, USA
Prize Motivation: "for mechanistic studies of DNA repair"
Sancar discovered the mechanisms used by cells to fix damage by ultraviolet radiation.
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