LATEST UPDATES » Vol 26, Nos. 11 & 12, November & December 2022 – Worlds Within Worlds – Viruses, Humanity, and the Environment       » Pinpointing How This Key Protein Facilitates Viral Transmission From Insects to Plants       » A New Approach to Treating Organic Wastewater       » Using Old Plants for New Tricks?       » Using Gas Bubbles as Lenses to View Tissues More Deeply       » Seawater as a Renewable Energy Source       » Generating Oxygen Within Cells
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Vol 26, Nos. 11 & 12, November & December 2022
Editor's Letter
Probing the Viral Dark Matter: How Marine Viruses Orchestrate Life in the OceanBy Vanessa Lunardi

Here, we explore some of the complex interplays between marine viruses, their hosts, and the environment.

Heralding a New Era of Dengue ManagementBy Junghun Justin Kim

Advancements in the dengue management landscape indicate a new era in the way we mitigate the impacts of the infectious disease.

Nipah: A Deadly Virus and the Pursuit of a Vaccine Before the Next Pandemic ArrivesBy Dr Sunny Himansu

Southeast Asia has seen her fair share of Nipah virus outbreaks. How do we stay ahead of the enemy?

Vol 26, Nos. 09 & 10, September & October 2022
Editor's Letter
How Nature’s Deadliest Venoms are Being Turned into Life-Saving MedicinesBy Vanessa Lunardi

Here, we explore the various drugs developed from snake venoms and future trends in venom therapy.

Toxins, Medicines, or Defence Mechanisms? The Multifaceted Nature of Plant Secondary MetabolitesBy Ng Yen, Tara

With over 200,000 known compounds, plant secondary metabolites are a diverse class of biocompounds with varied properties and applications. What are their uses in plants and may humanity benefit from them too?

Probiotic Lactibacillus casei Shirota and its Aflatoxin-Binding PropertiesBy Chang Wei Lin and Dr Mohd Sabran

Probiotic Lactobacillus casei Shirota (LcS) has been extensively reported to have aflatoxin-binding ability. Here, we discuss the available evidence and mechanism of action for aflatoxin-reducing properties. The possible factors affecting the probiotic efficacy in removing aflatoxin are highlighted.

Vol 26, Nos. 07 & 08, July & August 2022
Editor's Letter
Saving Lives Sustainably: Driving Environmental Stewardship While Innovating to Meet Unmet Patient NeedsBy Thomas Willemsen

As the healthcare and pharmaceutical industry continues to innovate lifesaving medicines and vaccines for better patient outcomes, it is essential that sustainable efforts remain at the forefront of these efforts.

Future Farming With Ocean CropsBy Alex Teo

With rising environmental pollution and increased strain of producing crops, we could look to the ocean as a viable alternative to traditional farming methods.

Saving the Northern White Rhino from ExtinctionBy Dr Sebastian Diecke and Steven Seet

The international BioRescue Consortium will save the northern white rhinoceros from extinction by using stem cell-associated techniques.

Reducing Medical Waste Through Sustainable Manufacturing PracticesBy Mr Goh Khoon Seng

With even more breakthroughs in new medical technology, waste is further generated as manufacturers deviate toward single-use devices. Inadvertently, the medical sector is well on its way to becoming one of the biggest pollutants on the planet, exacerbated in recent years due to the pandemic.

Vol 26, Nos. 05 & 06, May & June 2022
Editor's Letter
Identifying Links Between Mitochondria, Lipids, and Alzheimer’s DiseaseBy Dr Matthew Moulton and Dr Hugo Bellen

A recent study from the Bellen lab at Baylor College of Medicine and the Duncan Neurological Research Institute identifies novel links between Alzheimer’s disease (AD) risk genes and the build-up of lipids due to mitochondrial dysfunction.

Stem Cell Medicine Helping Us Live Better for LongerBy Dr Ross Macdonald

Cynata Therapeutics, an ASX-listed clinical stage stem cell technology company is working to prolong our “healthspan” so that we can live better for longer.

Age-Related Macular Degeneration and How We May Treat ItBy Vanessa Lunardi

As populations age globally, the incidence of age-related macular degeneration increases. To manage this, healthcare costs are expected to increase proportionately. Here, we discuss the eye disease and the potential treatments we can look forward to in the future.

Cancer Preparedness in Emerging MarketsBy Liz Henderson

How are the lower- and middle-income countries preparing for the challenges ahead, and what does the future have in store?

Vol 26, Nos. 03 & 04, March & April 2022
Editor's Letter
The Evolution of Human AdvancementBy Michelle Tan Min Shuen

As humankind progresses into a new era of science and technology, many natural hazards have been eliminated and selection pressures lessened. While the natural evolution of the human species seemingly grinds to a halt, a new era of human enhancement takes the wheel — reproductive genetic technology.

Choosing the Best – Selecting the Best Gametes and Embryos for Use in Assisted ReproductionBy Dr Sam Prien and Dr Lindsay Penrose

Do perfect-looking embryos always yield the best result? How do we select which embryos to use? How can we provide the best chances for pregnancy?

Blastoids – A Looking Glass for Early Human Embryonic DevelopmentBy Dr Alok Javali and Dr Nicolas Rivron

A faithful in vitro model of human embryos, as reported in our recently published study, allows for the first time to perform high-throughput and complex experimental manipulations to unravel previously unknown mechanisms and to develop novel therapeutic strategies for women’s reproductive health.

Vol 26, No. 02, February 2022
Editor's Letter
Shorter, Sharper Patient Pathways Are the Future of OncologyBy Kenneth Tan

What do companies, policymakers, and care providers need to do to take advantage of these emerging technologies and accelerate the patient’s path to treatment?

Why Research Is Vital to Find a Cure for Australia’s Most Devastating CancerBy Lance Kawaguchi

Find out how this not-for-profit is collaborating with researchers and industry to accelerate treatments to patients in the effort to rapidly increase brain cancer survival and improve the quality of life for people living with this disease.

HCC Treatment Update: TACE and Immunotherapy Combination Shows PromiseBy Dr Ahmed Abdelal and Dr Binta Patel

Combining locoregional treatments with immunotherapy shows promise, with ongoing investigations seeking to confirm the efficacy and safety of the modality to help improve patient care and outcomes.

Vol 26, No. 01, January 2022
Editor's Letter
Agile and Affordable Drug Development: The Future for Conquering CancerBy Dr Harish Dave

With the current paradigm shift towards precision medicine and patient-centricity at the core of drug development, the future is looking bright for cancer treatments.

The Role of Antimicrobial Coatings in the Reduction of Pathogen TransmissionBy Jade Pallett

As we try to limit the transmission of bacteria and microbes to contain the spread of diseases, what are surfaces we should pay particular attention to and how does the use of antimicrobial coatings outdo traditional modes of disinfection?

Vol 25, No. 12, December 2021
Editor's Letter
Towards a Secure Digital Healthcare Roadmap for RadiologyBy Christopher Khang

How innovative technologies such as AI, robotics, and automation are shaping a bright future for radiologists and their patients.

Connected Data at the Heart of Future HealthcareBy David Irecki

A unified view of patient data is key to an integrated, people-centric, value-based healthcare system where leveraging connected data, enables holistic, coordinated services, to improve people’s overall quality of life.

The New Future: What Role Does Smart Cleaning Play?By Lewis Ho

Innovative healthcare solutions to protect the next generations.

Vol 25, No. 11, November 2021
Editor's Letter
Healing Childhood Trauma Through Dyadic Relationship-Based InterventionsBy Dr Salam Soliman

The importance of early dyadic relationships to children’s development is well-documented in the literature, but what happens if an infant is exposed to multiple environmental risks, when early experiences are threatening, unpredictable, neglectful or abusive? This article aims to provide answers to this question and offer ways to mitigate the effects of trauma and adversity on the brains of our youngest children.

Vol 25, No. 10, October 2021
Editor's Letter
An Inquiry into Life in the UniverseBy Carmen Chan and Vanessa Lunardi

Are we alone in the Universe? How may life emerge elsewhere in the Cosmos? What is our future in the grand scheme of things? In this article, we dive into the field of astrobiology and planetary sciences and explore these questions in turn.

Comets, Panspermia, Culture, and PrejudiceBy Professor Chandra Wickramasinghe

We often think that science in 2021 is free from any form of irrational prejudice and is based only on irrefutable fact. In this article, we show that this is far from being true in relation to the biggest questions of science, particularly those that relate to the origins of life.

Vol 25, No. 09, September 2021
Editor's Letter
Alternative Proteins: The Rising Stars of the Next Decade By Monique Suryokusumo

As the world gears towards sustainability, Monique Suryokusumo from Monde Nissin Corporation shares about the current innovations in the alternative protein space and the key factors that will integrate it into the mainstream.

Vol 25, No. 08, August 2021
Editor's Letter
Cancer Cell Therapy: Looking to the Future of CAR T Cell Manufacturing By Yie Hou Lee and Michael Birnbaum

Manufacturing innovations in CAR T cell therapies could be a game-changer for many late-stage cancer patients.

The Spatial and Temporal Complexity of Glioblastoma By A/Prof Ang Beng Ti Christopher and colleagues

Addressing the critical issues underlying the difficulty in treating glioblastoma brain tumours.

Hereditary Cancers: How to Improve Your Odds in This Game of Roulette By Dr. Chi-Jui Liu and Hsiao Yun Lu

Several hereditary mutations have been identified since we noticed the relationship between genetic alteration and cancer formation. Knowing the type of genetic alteration involved will assist in making a wise risk-management choice.

Vol 25, No. 07, July 2021
Editor's Letter
Urban Ageing: Helping Our Elderly Live Safer and Easier

An interview with Asst Prof Tim Xu and A/P Wee Shiou Liang from Health and Social Sciences, SIT, on helping the elder live safer and easier lives.

Harnessing Technology to Enable Hope for GBM: Tumour Treating Fields By Dr Daniel Tan

In October 2015, the U.S. Food and Drug Administration (FDA) approved the use of a new treatment called Tumour Treating Fields (TTF) in combination with temozolomide chemotherapy for the treatment of newly diagnosed GBM.

Vol 25, No. 06, June 2021
Editor's Letter
SBRT offers for hope Inoperable Kidney Cancer

Renal cell carcinoma is the most common malignancy of the kidney. Its incidence has been steadily increasing over the past few decades. There are several reasons for this. Firstly, abdominal scans for screening or investigation of symptoms are being carried out with increasing frequency. As a result, more incidental kidney tumours are being detected.

Commemorating World Health Day with Viatris

This year’s World Health Day, we face unprecedented health disparities and overwhelming grief on a global scale, wrought by the COVID-19 pandemic. From every corner of the world, nations and communities unite to suppress the virus that has turned our lives upside down.

Vol 25, No. 05, May 2021
Editor's Letter
Digital Health for the Evolving Asian Healthcare Sector

The convergence of digital technologies is helping us lead longer, healthier, more empowered lifestyles. In Asia, increasing awareness around health and wellness is giving rise to a diligent, discerning type of consumer – one that is demanding more participatory, personalised, innovative approaches to healthcare. Healthcare providers and organisations that recognise, engage and reward consumers throughout their journeys will drive improved outcomes and benefit from strengthened relationships.

Exploring New Innovations to Advance Atrial Fibrillation Treatment

In this article, Dr Ma Changsheng shares about the innovations to help atrial fibrillation patients improve outcomes through early intervention and better management of the disease state.

Vol 25, No. 04, April 2021
Editor's Letter
Contributing to The Evolution of Medicine with Sony’s Technology - By Leonard Yap

The global COVID-19 pandemic has triggered dramatic changes in working practices of hospitals, especially strategies for treating and caring for high-risk patients. With every healthcare institution prioritizing the wellbeing of its staff, patients and visitors, we explore how Sony combines our technology to solve problems and strive for a society where everyone can live with peace of mind in the fields of diagnosis, treatment and education, help deliver improved patient care and medical education, as well as aid in transforming hospital workflows against the backdrop of heightened care needs and constrained resources.

Vol 25, No. 03, March 2021
Editor's Letter
The Silence of the LAMP - By Mark B. Carascal

As the demand for accurate molecular diagnostics increases, it is time for loop-mediated isothermal amplification assay, or LAMP, to make noise.

Rising Prevalence of Genetic Disorders among Global Population & Subsequent Interest in Gene Editing Technologies - By Saloni Walimbe

As a technology, gene editing has demonstrated myriad benefits for the medical industry over the years. Gene editing has tremendous potential in the treatment of inherited diseases, generation of more resilient crops, and even the detection of varying species in the environment.

Vol 25, No. 02, February 2021
Editor's Letter
Cultivating Future Innovators with STEM Education: Insights from STEM Conference 2020 - By Oh Sher Li

STEM Conference 2020, organised by Science Centre Singapore in November 2020, brought educators, researchers and industry experts together to discuss how STEM education in Singapore and worldwide is evolving and adapting to the changing global landscape.

Editor's Letter

Are We Ready to Ship Billions of COVID-19 Vaccines Worldwide? - by Kawal Preet

What does it take to ship a crucial vaccine to stop a global pandemic? The healthcare industry is facing an enormous logistical challenge – and FedEx is at the frontline, ready to deliver.

How Biomanufacturers Must Innovate to Embrace Industry 4.0 - by Pierre Kardasz

Since the COVID-19 outbreak was formally declared a pandemic to the time of writing, with close to 50 million individuals infected,1 and the global economy experiencing its worst recession since the Second World War,2 the impact and associated costs of a healthcare crisis cannot be underestimated.

Editor's Letter

Emerging Class of Cancer Therapy Agents - by Deborah Seah

An emerging class of anticancer drugs known as vascular – disrupting agents (VDAs) have been developed through preclinical and clinical trials that function to selectively target the formed blood vessel network on the tumour to cause tumour necrosis.

Unlocking the Key: Genetic Links to Diabetes in Asia - by Deborah Seah

Diabetes is a fast-growing epidemic in Asia. With more than 60 percent of people with diabetes in the world living in Asia, it is a public health concern as the number of diabetes cases increases each year. Genetic studies on diabetes in Asian populations could therefore provide answers linking pathophysiology and genes that could pose increased risk of diabetes.

Editor's Letter

See things through: How Artificial Intelligence Assist Humans in Combatting the COVID-19 Pandemic

In the heyday of artificial intelligence (AI), many were afraid to lose their jobs to something initially designed to make lives better. Amid the COVID-19 outbreak, AI has come to their rescue, and has been tremendously used to protect the whole world for a better and safer tomorrow.

Revolutionising Drug Discovery with Artificial Intelligence - By Deborah Seah

Drug discovery is the first step towards the development of new therapeutics. From the first screening to the launch of preclinical testing the process is long, coupled with high cost and uncertainty, how can artificial intelligence technologies help to accelerate this process and make it for effective?

Editor's Letter

Broadening Horizons of 3D Printing - By Deborah Seah

Over 30 years ago, one of the earliest forms of 3D printing technology was filed for a patent by Chuck Hull. Since then innovations and modifications to this emerging field has made possible its applications to a wide range of industries, from manufacturing to biomedical science.

Exploring the Revolutionary World of 3D Printing

A chat with a 3D printing specialist, Dr. Sunpreet Singh, Research Fellow at the Department of Mechanical Engineering, National University of Singapore.

Editor's Letter

Studying Parkinson's Disease Genetics in Asia

Recent genetic studies on Parkinson's disease in Asian-ancestry individuals have demonstrated important differences in genetic risk between Asians and Europeans. Extensive collaborations across the Asia- Pacific region are needed to develop a comprehensive resource of genetic information and tissue samples that will contribute further to our understanding of the disease.

Charting Neuron Paths: Mapping the Human Brain

Generating a comprehensive map of the human brain can provide valuable insight to our neurological circuitry and how brains function. Scientists and researchers in the field work to map a whole human brain and leverage on technological advancements to store this potentially large dataset.

Editor's Letter

Food Security in Asia-Pacific: Challenges and Potential Solutions

Interview with Peter Ford, President, Asia Pacific for Corteva Agriscience Agriculture Division of DowDuPont and Priya Bapat, Senior Consultant, Public Policy for The Economist Intelligence Unit, on the Global Food Security Index 2019 Asia Pacific regional report.

A COVID-19 Pandemic Reality: Impact on Food Security - By Deborah Seah

Besides its strain on healthcare systems, the COVID-19 pandemic of 2020 has brought many industries to its feet. Not sparing the agri-food industry, its implications raised red flags on the food security within the region.

Editor's Letter

The Unreported Statistic of the COVID-19 Crisis

With the daily spotlight on infection count, hospital situations, and latest governmental measures to open up the economy, the psychological impact of the pandemic has somewhat been neglected. APBN talks to Samaritans of Singapore (SOS) about the mental health situation in Singapore.

Building Technology for the Fight against COVID-19

Well-known for its digital healthcare platforms, Tencent Healthcare will not be shying away from the recent COVID-19 pandemic. Its latest launch of open-sourced COVID-19 self-triage AI-powered tools further proves Tencent Healthcare's commitment for providing technology to bridge gaps in the healthcare industry.

3D Printing to the Rescue: Hands-free Door Opener for COVID-19

3D printing companies have unexpectedly flourished in the present climate amidst relentless demand for medical equipment such as protective gear and respirator valves. Belgian manufacturer Materialise has joined the bandwagon with their own ground-breaking innovation: a hands-free door opener.

Editor's Letter

10 minutes to screen 4,000 drugs
By Shaun Tan Yi Jie

Drug discovery is slow, expensive and cursed with high failure rates. As the COVID-19 outbreak screams for a cure to stop it, Deargen Inc. shows the world how to exploit artificial intelligence (AI) to expedite the process and increase changes of success.

Remdesivir: Humanity's hope against COVID-19?
By Shaun Tan Yi Jie

While research for a vaccine plods on, Gilead's remdesivir is emerging as the best stopgap measure to halt the relentless march of COVID-19 across the globe.

Epidemiology of COVID-19 and Perspectives from Chinese Medicine

Authors Dr. Vivian Wong and Dr Chris Chan bring to light a perspective of using Chinese Medicine for the treatment of COVID-19.

Tiding of the Outbreak
By Deborah Seah

An exclusive interview with Dr William A. Haseltine, Chair and President of ACCESS Health International Inc., on the lesson learnt and priorities so far for the COVID-19 global pandemic of 2020.

The Study for the Prediction of the Turning Period for Outbreak of COVID-19 Spread in China based on the iSEIR Model1 [Online Exclusive]

The goal of this study is to report how to establish a general framework for predicting the so-called critical "Turning Period" in an infectious disease epidemic such as the COVID-19 outbreak in China early this year.

Editor's Letter

Fastest or Most Precise?
By Shaun Tan Yi Jie

As companies and universities around the world scramble to develop fast and accurate test kits for the detection of COVID-19, two have thrust themselves into the spotlight: University of Macau, which constructed a kit that takes less than 30 minutes for analysis, and Novacyt, which designed a test that detects only the 2019 strain of the virus.

The Viral Solution

Ebola virus, HIV, SARS virus, and just recently, COVID-19 — we commonly associate viruses with some of the deadliest infections in history. However, did you know that the next "wonder therapeutic" that could save the world may actually, be a virus?

The Modern-Day Nostradamus: George Yuan Xianzhi
By Shaun Tan Yi Jie

Dr. George Yuan, distinguished professor of Center for Financial Engineering in Soochow University, correctly predicts COVID-19 peaking in China by mid-February using a mathematical model called iSEIR.

Coronaviruses: A Primer Part 2
By Judy Yeo

In the continuing series on the COVID-19 outbreak, APBN takes a closer look at coronaviruses to help readers better understand the feverish pace of work undertaken by researchers and scientists in the race to find solutions to the COVID-19 outbreak which has wreaked havoc in most parts of Asia and across at least 60 countries outside of China.

Editor's Letter

Dawn of the Big Machine
By Dr. Melvin L.K. Chua

The War against Nasopharyngeal Carcinoma

Overcoming Cultural Barriers to SSI Prevention Guidelines
By Dr. Keita Morikane, M.D., PhD

Guidelines represent consensus - in thinking, expertise and practice. They, in theory, reflect communal alignment. In the area of Surgical Site Infection (SSI) prevention, evidence-based guidelines seek to minimise risks, improve health outcomes and reduce unnecessary variations in care throughout the surgical continuum.

Editor's Letter

Supporting Patients in Management of Diabetes

Diabetes is a disease that does not rest, patients with the chronic disease will have to be diligent in managing it daily. With majority of the time diabetes care requires self-management, the development of a reliable and effective personalized management system can benefit patient for positive clinical outcomes.

Connectivity in the MedTech Sector

A report by McKinsey in 2015 on the MedTech scene in Asia predicted that the MedTech sector to expand to about USD 133 billion a year in 2020. We present expert commentaries on how connectivity is essential in the ever-growing MedTech sector in Asia Pacific.

Editor's Letter

Repurposing of Waste

Developing sensors from laboratory waste materials

Brain Tumours: Identifying Patients for Targeted Therapy

Using gene signatures with a unique characteristic pattern of gene expression seen in aggressive brain tumours, scientists were able to develop and identify key elements for precision medicine in the treatment of these tumours.

Metabolic Imaging

Opening new perspectives in treatment of metabolic diseases

Editor's Letter

Soaring MedTech Industry Faces Skills Shortage

A deep dive into the talent needs of the MedTech industry in Asia Pacific

The Future of Food is Meat-Free

By 2050, we will have to feed nearly 10 billion people. With the constant impact of current food manufacturing on the climate and expanding populations, changes have to be made.

Spend Less to Combat Cancer Better?

Insights and critique on the deployment of genomic profiling technology in cancer management.

Editor's Letter

Ensuring food security for the future

Apart from providing the technology, we also need to look into how these technologies are delivered to the hands of the growers. — By Andre Oliveria

Natural products produced by fermentation hold potential to help Singapore's farming economy grow

SMART team's genetic breakthrough set to improve crop yields in urban farms — By Dr Kang Zhou and Dr Sarojam Rajani

Editor's Letter

The Science of Healthy Ageing

With expanding ageing populations throughout the world, research efforts to promote healthy ageing has shown that biomarkers are linked to the ageing process and age-related disease manifestation. Thus, providing potential for supplementation of biomarkers to mitigate diseases and encourage healthy ageing.

Precision medicine in oncology: charting advancements and next steps in Asia

In the Asia Pacific region, precision medicine in cancer treatment has come a long way, but according to Vishal Doshi, CEO of AUM Biosciences, we still have work to do in ensuring that we translate research into tangible outcomes for patients.

Editor's Letter

The future of predicting lifestyle diseases is here in Asia

Early detection of lifestyle diseases through blood tests catered to the Asian Pacific region can be a preventive measure for these diseases.

Breaking Barriers for Artificial Intelligence in Healthcare

Prizing the people whom AI is designed for, over the AI that is designed for them.

Overcoming Challenges of Managing Information in Life Sciences

Leveraging advanced technologies, such as digital solutions can help life science firms make sense of the massive level of information they generate and lead to new discoveries that can streamline clinical trials, accelerate the development of new medications and increase supply chain efficiency.

Under the Weather: Cybersecurity Woes in the healthcare Industry

With increasing concerns for cybersecurity in the healthcare industry, analysis into the anatomy of cyberattacks will provide a fighting chance to counter them.

Editor's Letter

Emerging treatments for spinal cord damage

Can damaged nerves regenerate? by Dr. Jerry Silver

Dementia, Alzheimer's, Parkinson's — Confusions, myths and tips

As Singapore confronts an ageing population, diseases associated with the ageing process are rising to the fore. In this article, we clear up certain misconceptions and impart some basic knowledge on common neurodegenerative disorders. by Shaun Tan Yi Jie

An update on Alzheimer's disease

Although Alzheimer's currently has no cure, treatments for symptoms are available. Research has come a long way since 1990s and the emerging biology-based biomarker approach will pave the way for understanding, controlling, and possibly curing this debilitative disease. by Associate Professor Helen Zhou

Integration of Traditional Chinese medicine and Western medicine in cancer treatment

Cancer is one of the diseases with high morbidity and mortality in the world. Traditional Chinese medicine (TCM) plays an alternative and complementary role in adjuvant cancer therapy. However, TCM still has many controversial problems in cancer therapy, such as the name and diagnosis of cancers, unscientific theory and lack of english evidence-based studies. This article explains how TCM can be integrated with western medicine in cancer therapy, in the hope to gain recognition from the western medical world. by Ng Pu Jue

TCM's integration into modern health system

A philosophical illustration and medical approach to TCM's role in mainstream healthcare. By Dr. Loh Cheng Toa Steven

Editor's Letter

What's in a name of a clinical trial?

SUNRISE, BATMAN and GEMSTONE, who comes up with these names? By Lim Guan Yu

The ABCs of clinical trials

Clinical trials are the make-or-break stage of a drug's long journey from initial discovery to eventual commercialisation. What happens in clinical trials? Who are involved? Why is the failure rate so high? We delve into the dark side of the pharmaceutical industry to answer these questions. By Shaun Tan Yi Jie

The hyper-intelligent clinical trial

Ross Rothmeier shares how AI is being applied in the recruitment process of clinical trials

Three criteria to consider when selecting a CRO partner

Rising IND submissions are driving preclinical CRO market growth in Asia. Charlene Chen shares three criteria when selecting a CRO partner that can take you from preclinical through Phase II and beyond.

Editor's Letter

How the largest birds on Earth and their strong immune systems lead to a breakthrough in antibody technology research

Ostrich antibody may just be the breakthrough technology needed in the biotechnological world. From daily commercialised products for prevention to promising findings in diagnostic and therapeutic, ostrich antibodies hold possibilities for everyone in the future. by Fadhilla Khairaruni

Editor's Letter

Transitioning between academia and industry in the life science sector

Duke-NUS Medical School researchers say the key to transitioning successfully between academia and industry is to highlight skills in teamwork and meeting deadlines. by Lim Guan Yu

Preparing students for jobs that do not exist now — The changing face of global talent in A.I. age

In the age of artificial intelligence, how should you nurture talents for future careers that are unknown? In this article, Prof Roland Chin also shares the role of liberal arts education in universities in this era of AI.

Editor's Letter

Renal complications of oxalate disorders

Improving our understanding of oxalate disorders may provide an opportunity to target the gut to treat kidney stone disease. by Dr Annamaria Kausz and Dr Zhiqun Zhang

Editor's Letter

Just in time for the New Year: Medical marijuana

Marijuana or cannabis, most commonly referred to as weed and pot, is often associated with the unruly use of drugs. Yet, how many recognise the use of marijuana for medical purposes? We take a closer look into how marijuana is incorporated into medical practice and the first country in Southeast Asia to legalise the use of the drug to treat specific illnesses. By Lim Wan Er

The medical cannabis landscape

Legal cannabis is opening up but research is the key to long term earnings. By Dr Sean Hall

Cannabis: From seed to product

We take you through the various life stages of a cannabis plant from seed to harvest and post-harvest processing steps. By Lim Guan Yu

Patient misconceptions about opioids

Cancer pain is not a fatality — as long as patients don't reject the remedy. By Dr. Gouri Shankar Bhattacharyya

Editor's Letter

Taiwan medical tourism – Taichung Veterans General Hospital & China Medical University Hospital (Taichung)

Known as a popular tourist destination in Asia, Taiwan is promoting its medical tourism industry. Read on to find out two hospitals with different specialties.

Asia-Pacific: Falling behind in the fight against HIV/AIDS

Asia-Pacific has shown important leadership on HIV/AIDS and has made solid progress towards controlling the epidemic in the region. In this op-ed, however, the authors draw attention to recent indicators suggesting that Asia has fallen behind in the fight against HIV/AIDS in key areas compared to other regions of the world. After summarising some of the obstacles to achieving epidemic control, such as widespread stigma and discrimination, the authors offer possible solutions for how the region can close gaps in HIV testing and treatment.

Editor's Letter

The Asian cancer

Battling Asia's war on liver cancer. By Dr Choo Su Pin

Eliminating viral hepatitis in Indonesia by 2030

Dr Jack Wallace shares an understanding of the silent disease burden in Indonesia and recommendations that can offer potential guidance for policymakers in countries throughout the region and around the world to eliminate the virus.

Liver cancer treatments - A decade later

The last liver cancer drug, sorafenib was approved in 2007. After a decade, drugs like regorafenib, nivolumab and lenvatinib are showing potential in treating hepatocellular carcinoma.

Like a sniper

Radiation oncologists use breath hold techniques to shoot tumours with little collateral damage. By Dr Jonathan Teh

Hepatocellular carcinoma detection using artificially engineered materials

Two techniques using artificially developed materials, THz metamaterial and aptamer-based techniques for liver cancer diagnosis are explained in this article. Both methods hold great potential for ultrasensitive detection at the incipient stage of cancer development. By Vinod Kumar Khanna

Editor's Letter

Is soy consumption linked to breast cancer?

Soy products constitute a huge part of our diet and daily intake, since it can be found easily and is a highly versatile ingredient used to make everyday food products. However, for breast cancer patients and those at risk, is consuming soy a boon or bane? We explore both sides of the theory that soy increases risk of recurrence and appearance of breast cancer. By Lim Wan Er

Preventative mastectomy on the rise

A mastectomy may not be suitable for everyone, but it is a life-saving measure that more patients are opting for, especially individuals predisposed to breast and ovarian cancers. By Catherine Domingo Ong

Editor's Letter

Healthcare heads into the digital future

From expediting diagnosis to enabling remote patient monitoring, smart technologies are playing a key role in improving patient outcomes, lowering costs, and creating efficiencies in today's healthcare. By Nalin Amunugama

Digital technology improves research and management of functional gastrointestinal disorders in babies

Digital tools can be employed in research to gather data efficiently, improve scientific insights, and support in the diagnosis and management of infant colic, regurgitation, and constipation. by Dr Thomas Ludwig

Welcome to the healthcare revolution

Dr Mark Burby tells us more about the potential of artificial intelligence in healthcare, from treatment and diagnostics, to predictive medicine and wellness.

Doctor Robot will see you now

The healthcare industry, which is facing a severe human resource crunch, is getting a shot in the arm in the form of automation technolo
By Swaminathan Vangal-Ramamurthy

Maximising human potential in the age of AI

Dr Vivienne Ming challenges ideas about bias and the human potential in education and the workplace. Her research and tools involving machine learning, neuroscience, sociocultural interventions, and behavioral economics help us better explore the future of human potential.

The Internet of Things in healthcare - A double-edged sword?

Personal health information are now more valuable than credit card data on the black market. Sara Jost shares three ways the healthcare sector can use to protect against cyberattacks and their terrible consequences.

Data could help Asia cope with its ageing population

The elderly population in Asia is becoming one of the oldest in the world. What can be done to ensure their healthcare needs for quality of life are met? by Rick Scurfield

A vision of connected healthcare delivery in Asia

Nicole Hill explains how improved connectivity can optimise care pathways, arguing that a scalable and secure network is the prime enabler of smooth digital transformation initiatives in the healthcare sector.

Editor's Letter

Lab-grown meat: Better for you and the environment

Learn more about the future of food. By Melita Brainta

Regenerative medicine: The future of healing

Let's take a closer look at how science makes use of the human body's ability for regeneration to generate new therapies.

Editor's Letter

POREX, a key player in water technology

Effective conductivity analysis in the CIP process for pharmaceutical manufacturing

Clean-in-place (CIP) processes are important for ensuring high productivity, safely and compliance in pharmaceutical industries. To do that, understanding conductivity measurement can help improve the effectiveness and efficiency of CIP. By Ryo Hashimoto

Editor's Letter

Artificial Intelligence: saving lives and securing the future

Artificial Intelligence is helping security and medicine become more efficient through the use of pattern recognition and improved applications of neural processing locally vis-à-vis moving data offsite to a cloud server. By Dr Manan Suri

The best pill for cancer patients: An exercise regime

Exercise is the 'best medicine' and should be prescribed to all cancer patients alongside conventional cancer treatments, says researchers from the Clinical Oncology Society of Australia. By Lim Wan Er

Across the divide: Multidisciplinary team to achieve better outcomes for breast cancer patients

The treatment of breast cancer requires a multidisciplinary approach. Read on to find out the roles of the various medical specialists working together as a team to battle breast cancer.

The state of cancer research in Asia

Prof David Virshup shares in this interview, the state of cancer research across the globe, and the latest developments in this space in Singapore and Asia.

Clinical utility of and access to cancer molecular diagnostics in Asia

What's in it for me? Learn how molecular diagnostics can or cannot transform the care for cancer patients in Asia. By Dr Allen Lai and Dr Maarja-Liisa Nairismagi

Reprogramming the immune system against cancer

Immunotherapy holds the potential to transform the standard of care for cancer patients. By Dr John E. Connolly

Editor's Letter

Adding value through additive dentistry

Tooth wear is a normal physiological process which can affect aesthetics, function, and even cause pain. Additive dentistry helps to preserve the existing tooth structure, making it a healthier and superior treatment option to traditional reductive methods. By Dr Christopher Ho

Dental care for the silver generation

Professor Finbarr Allen talks about understanding the needs and demands of the elderly for oral healthcare.

Digitising Dentistry

Dr Andreas Kurbad talks about the rise of technology in dentistry. He has has been running his own dental practice specializing in cosmetic dentistry and implantology since 1990.

Dental dangers - Poor oral health and NCDs

The bare facts on why maintaining those bright pearly whites is important for physical health. By Pearly Neo

Editor's Letter

Take a gut look

Discovering the digestive health advancements of the 21st century
by Pearly Neo

Editor's Letter

Empowering nutrition via biotechnology

In the midst of an ever-increasing global population, how can biotechnology address emerging nutritional issues? By Pearly Neo

Feeding Asia's children

Asia is home to nearly two-thirds of the world's malnourished, with an estimated 87 million children under the age of five stunted. This article discusses the current trends and insights on Asia's nutrition landscape, including what needs to be done to address the challenges for low to middle income groups, especially children. By Dr Femke Hannes

Editor's Letter

Ageing in the age of science

What does it mean to age in the accompaniment of science and technology? By Pearly Neo

Assistive technology: a benison for the disabled and elderly

New developments in the medical community have always contributed to the welfare of the geriatric population and differently abled citizens. The matter of fact that the ability and feasibility of elders to cope up with their feeble health at home settings has been a pain point for years. Safety is another critical factor that has added to the woes of the developers of such systems. However, recent advances in assistive technology has been a silver lining for the distressed. Garima Chandra and Soumya Das elaborate on this.

Editor's Letter

Keep the weight off, keep diabetes at bay

In a breakthrough in diabetes research, study shows that a strict low-calorie diet can beat the condition without drugs.

Tackling obesity in ASEAN

Country profiles of the prevalence, impact, and interventions on obesity in six ASEAN countries.

Editor's Letter

New hope for butterfly children

Epidermolysis bullosa is a genetic disease which causes severe skin damage. There is no cure for it and about four in 10 patients do not reach adolescence. Recently, in a project funded by the Austrian Science Fund FWF, a research team from Salzburg developed an ointment for the treatment of butterfly children. In Germany, a boy was given a new genetically modified skin that covered 80% of his body, in a series of lifesaving operations. Read on to find out the advances in the treatment of this genetic disease.

Living with food allergy

Allergies exist in many different forms and they can be induced by the environment, drugs, food, and others. These allergens can trigger an allergic reaction, requiring clinical care by a physician or a health care professional. Let's hear from Catherine Ong, who talks about her own encounter with a food allergy.

Editor's Letter

Getting to the root of the problem

Dental caries in children can be aggressive if it is not diagnosed and treated in a timely manner. Dr Bien Lai Wen Pui says early dental visit at age one and preventive advice for parents are recommended before dental caries occur.

Millions of newborn infants in Western Pacific still at risk

A newborn dies every two minutes in the Western Pacific Region, largely due to inappropriate clinical practices at the time of birth, and during the first few days of life. Newborn deaths, however, are often preventable. Essential Newborn Care is a solution to significantly reduce newborn deaths.

Deciphering molecular clues to paediatric urinary tract infection

Urinary tract infection (UTI) is one of the most common bacterial infections in children, and being able to identify patients with UTI who are at risk of kidney damage at an early stage is key to the development of better approaches to treatment and prevention, says A/Prof Chao Sing Ming.

Editor's Letter

A matter of the heart

APBN talks to Assoc Prof Philip Wong to get insights on a potential drug treatment for high-risk patients dying from sudden cardiac death.

Discovering opportunities in China's cardiovascular market

China has one of the world's most complicated and regulated healthcare industries. Jelte Wingender gives insights on China's cardiovascular drug and device market and the outcome of their healthcare reforms.

Improving outcomes and expanding indications with Transcatheter Aortic Valve Implantation (TAVI)

The narrowing of the aortic valve comes with aging and open heart surgery is often the conventional method to treat this. But for elderly patients and those with debilitating diseases, the surgical risk for open heart surgery is high. Dr Paul Chiam shares a minimally invasive method termed TAVI and the efficacy and safety of this method.

Community-based cardiac rehabilitation in Singapore

Cardiac rehabilitation (CR) programmes for patients after a cardiac episode or heart surgery, have been shown to improve patient outcomes like reducing mortality and as such, CR is an important avenue to deliver effective preventive care. The benefits of CR have been reviewed extensively in Western countries, but the impact of Singapore's CR programme on clinical outcomes have not been known until last year. Tay Hung Yong shares the findings.

The gift of life: 50 years of human heart transplant

On 3 December 1967, Christiaan Barnard performed the world's first human heart transplant on 53-year-old Louis Washkansky at Groote Schuur Hospital in Cape Town, South Africa.

Editor's Letter

Antivirals Targeting Host Proteins: A Feasible or Suicidal Approach in the Treatment Against HFMD?

Justin Jang Hann Chu and Tian Sheng Lew discussed the pros and cons of developing antivirals that target crucial host factors.

Vaccination against Infectious Diseases More Important than Ever

by Dr T. Anh Wartel, Regional Medical Expert for Dengue in Asia Pacific at Sanofi Pasteur

Mosquito-borne infectious diseases: Crafting an Asian solution

Asia has the highest incidence of dengue in the world. The fight against mosquito-borne diseases in Asia is at a critical moment in time says Dr Benjamin Rolfe.

The Ebola Epidemic: Why So Many Deaths Resulted

The major countries affected by Ebola - Sierra Leone, Liberia and Guinea, were among the most ill-equipped to deal with such a large scale epidemic. Much misunderstanding between response staff and affected communities hindered help as well.

Editor's Letter

Current and Emerging Diagnostic and Therapeutic Developments in Age-Related Macular Degeneration (AMD)

Age-related macular degeneration (AMD) is characterized by aging changes in the retina, the presence of drusen and a thin choroid. AMD accounts for 8.7% of blindness worldwide and is the most common cause of blindness in developed countries in the elderly.1 Due to an increasing aging population, it is projected that AMD will affect 196 million people in 2020, increasing to 288 million in 2040.1 AMD can...

International Collaborative Research Program focusing on Aging

The future of our health system depends on having a critical mass of researchers with the international knowledge necessary to meet current challenges. Singapore National Eye Centre (SNEC) and Singapore Eye Research Institute (SERI) have tremendous strengths, including the relative strength of our strong research base. To further strengthen our basic science research, we are working together with...

Anterior Segment Optical Coherence Tomography Angiography (OCTA)

Optical coherence tomography (OCT) is now a common imaging technique used in our ophthalmology practice, especially to evaluate anterior segment and corneal conditions.1 Recently, we were the first to describe the adaptation of OCT technology to provide static angiography images for the cornea and anterior segment.2 Angiography for the anterior segment has a variety of clinical applications, such as...

Clinical Trials in our Real World

Physicians are constantly inundated with new clinical trials purporting benefits of a new therapy or treatment regime. Consider the treatment of exudative age related macular degeneration (AMD) with anti-vascular endothelial growth factors (anti-VEGF), for example. Numerous clinical trials including ANCHOR1, MARINA2, CATT3, VIEW4 and many more have promised visual gains of 7-8 letters. Yet when...

Ophthalmology Workforce Planning and Projection — A New Integrated Approach

Health administrators and their human resource teams are often plagued with the difficult task of a timely assessment of future needs for the healthcare workforce. Healthcare forms a large proportion of the national budget in many countries, with healthcare manpower costs amounting to 60-70 percent of the healthcare budget. The size of the health workforce directly influences population health...

Editor's Letter

Future Foods for Health: Innovations in Dietary Modifications for Diabetes

Type 2 diabetes (T2D) affects 415 million people in the world today. This number is expected to rise to 642 million by 2040. In Singapore, the Ministry of Health has declared a "War on Diabetes". Major efforts will be made over the next 2-3 years to develop and deploy programs to prevent diabetes, and improve the care of patients with diabetes with a focus on optimizing care in a sustainable manner...

Kosmode Health: Technology that Expands Access to Health from Nature

Consumers today do not just want food. Yes! not even healthy food. They want food that keep them healthy i.e. functional food. Neither do consumers want supplements, they are demanding plant-based supplements. Consumers are speaking with their wallets, paying top dollars for quality plant based products, driving the rapid growth of the multi-billion dollar phytochemical nutraceutical industry...

Halal Certified Food: Processing, Technology and Regulations

How is 'Halal' defined? How is the process to certify food as Halal? Halal is the Arabic word for 'permissible' or 'lawful.' When used in the context of food, 'halal' refers to food that is permissible according to Islamic law or Sharia law. The strict scrutiny prohibits any food product that contains pork or is contaminated by any by-products that are porcine sourced, like gelatin or emulsifiers. It also...

Editor's Letter

Shire Championing the Cause for Patients with Rare Diseases

Rare diseases are highly complex and over 50% of rare diseases begin in childhood. 30% of children born with a rare disease are unlikely to see their 5th birthday [1,2]. Some examples of rare diseases are hemophilia, Gaucher disease, Hunter syndrome, Pompe disease, and so forth. Today, the majority of rare diseases are still unknown and yet to be fully understood. Through its sharp focus on rare diseases...

ASEAN+ Rare Disease Network: Unifying Voices of Patients

Rare diseases are complex and only 5% of 7,000 rare diseases have treatment approved by FDA. Affecting 350 million people worldwide, it is estimated that 50% of rare diseases begin in childhood [1]. Those affected by rare diseases do not receive a lot of attention. So how then can we help them effectively? We don't have the answer yet but the newly formed ASEAN+ Rare Disease Network seems...

Rainbow Across Borders

Formed in 2015, Rainbow Across Borders (RAB) aims to improve the quality of life of, and give dignity to, patients and families challenged by chronic or life-threatening illnesses. RAB is Asia's first regional patient support group alliance which promotes regional collaboration and networking among patient support organisations with the aim to empower the organisations through appropriate programmes...

Genetic Counselling Services in Malaysia

Medical genetic services started 10 years ago in Malaysia. Currently, there are five health centres (1 public hospital, 3 university hospitals and 1 private hospital) which provide medical genetic services in the health care system. Two senior clinical geneticists from the public hospital provide genetic service as an outreach service to five other public hospitals in different states in Malaysia. The Genetic...

Editor's Letter

microRNAs in Huntington's disease

Huntington's disease (HD) is a human inheritable autosomal dominant disease, and this disease is caused by a mutation of CAG trinucleotide repeats in exon 1 region of Huntingtin (HTT) gene (1993). In principle, the longer of CAG trinucleotide repeats, the more severe the HD. As a result, expression of mutant HTT leads to toxic gain-of-function, forming cytotoxicity inside cells (Li and Li 2004, Yang and...

Spatiotemporal Control of Hox Genes by microRNA

Hox genes have been extensively studied for more than 30 years. Although it is well-known that Hox genes are essential to the specification of spinal motor neuron subtype identities along the rostrocaudal axis, it remains unclear how the Hox genes are precisely regulated to achieve their collinear spatiotemporal expression. In collaboration with Prof. Qing Nie from the Mathematics Department of...

REVIVE Your Brain

Very often, people put efforts in maintaining their physical health and appearance, but neglect the fact that the brain ages together with the body. At a cellular level, the brain begins to age when we are in our early twenties. When brain cells age, their ability to communicate effectively with one another decreases, causing our cognitive and memory skills to decline naturally. As such, the brain requires...

Editor's Letter

Understanding Diabetes

Diabetes is a long-term condition in which the blood glucose levels of a person remain persistently higher than normal. It occurs when the pancreas does not produce enough insulin or when the body cannot effectively use insulin. Insulin is a hormone produced by the pancreas that allows your body cells to use blood glucose (sugar) for energy. Food is converted into glucose before it is absorbed...

Prediabetes: The Gap between the Onset of Disease and Initiation of Treatment

The global shift from communicable to chronic, noncommunicable diseases, including the increasing prevalence of obesity, prediabetes, and Type 2 Diabetes Mellitus (T2DM) creates a considerable challenge to the clinician and public health infrastructure. Despite substantial research efforts highlighting the considerable benefit of lifestyle modification in thwarting the insidious progression to...

Diabetes: A Dietitian's Perspective

What is diabetes? Diabetes is a condition that affects the way your body uses glucose as energy from food. People with diabetes have a high level of glucose in their blood. This is due to either insufficient insulin being produced by the pancreas or body not accepting insulin it produces, called insulin resistance, or a combination of both. The other reason is that the body does not produce insulin...

Use of Modelling for Better Diabetes Care

About 75 million people in Southeast Asia have diabetes mellitus (DM), a group of metabolic diseases caused by defects in insulin secretion or action. DM patients face higher risk of long-term complications such as damage to their vital organs - heart, eyes and kidneys - and nerve damage (neuropathy) [1]. The burden of this disease is getting heavier as the number of people in Southeast Asia with DM is...

No More Highs and Lows with Toujeo®: A New and Improved Insulin Injection

Sanofi has launched Toujeo®, a new generation innovative basal insulin designed to improve diabetic patient treatment experience. This long acting insulin is used to control blood glucose level in adults who have Type 1 (T1D) or Type 2 diabetes (T2D), and has been approved by the Health Sciences Authority (HSA) in Singapore as of February 2017. Diabetes is a condition where the sugar level in...

Editor's Letter

Can Chinese Medicine and Biomedicine Converge?

The eminent and iconoclastic physician William Osler famously said: "The good physician treats the disease; the great physician treats the patient who has the disease." [1] Osler held the Regius Chair for medicine at Oxford and was a founder of Johns Hopkins Medical School in America. He would have received positive endorsement from traditional practitioners of Chinese medicine who, though...

Integrative Medicine: East Meets West

The World Health Organisation (WHO) defines health as "a state of complete physical, mental, and social well-being and not merely the absence of disease or infirmity" [1]. This definition has remained unchanged since 7 April 1948. In this era of evidence based medicine, precision medicine and personalized medicine, how does one strive to achieve optimal health as defined by WHO? The key...

Ginseng: Nature's "Cure-All"

It is one of the most well-known and widely-researched herbs when it comes to traditional Chinese Medicine. There are several evidence-based benefits for one's well-being that some even refer to ginseng as a natural cure-all. It is considered as an adaptogen, which means it helps with mental and physical stress. Western medicine practitioners, however, don't necessarily believe this is always the...

Editor's Letter

Cancer in Women - Trends in Singapore

In November 2016, two reports highlighted the gravity of cancer trends in women worldwide. The American Cancer Society conducted an analysis [1] that concluded a 60% increase in cancer deaths (5.5 million per year) in women was expected by 2030 - it now kills 1 in 7 women (3.5 million in 2012), the 2nd highest cause of death after cardiovascular disease. The Lancet paper [2] estimated a doubling in...

Impact of Subsidies on Genetic Testing Uptake in Singapore: Is it Feasible?

Cancer is the leading cause of mortality in Singapore [1,2], a similar pattern is observed in other Asian countries and the world. Cancer is the uncontrolled proliferation of cells that arises due to the accumulation of mutations in genes that regulate the cell cycle. Identifying the factors that cause or drive mutations is often the focus of much cancer research and the findings of which help inform...

The Future of Radiation Oncology

Researchers have long recognised that although termed the same way, each individual cancer is distinct and unique. For oncologists, the quest to personalise treatments is more important than ever. In the ideal future state of radiation therapy treatment, a newly diagnosed cancer patient would first undergo a tumour radiosensitivity assay to estimate the tumour's response to radiation. Based on the patient's...

Targeted Therapies in Oncology: Where We Are and What Lies Ahead

"Cancer's life is a recapitulation of the body's life, its existence a pathological mirror of our own"- renowned physician Dr Siddhartha Mukherjee eloquently describes cancer's intricate identity. Interestingly, this similarity also forms the fundamental challenge in cancer therapies - the ability to kill cancer cells vs normal cells. Traditional chemotherapy drugs that attack rapidly dividing cancer cells...

Editor's Letter

Chronic Obstructive Pulmonary Disease - COPD

When breathing, we inhale air into our lungs down the bronchial tubes that branch out into many smaller tubes called bronchioles. At the end of those are alveoli: the round elastic sacs that contain air and allow the capillaries to run through their walls and collect the vital oxygen that will then continue its journey in our bloodstream. The oxygen in the alveoli is exchanged against carbon dioxide, the organic...

Lung Cancer Treatment

Lung cancer is a type of cancer that develops in the tissues of the lungs, usually in cells lining the air passages. [1] It starts when the cells become abnormal and grow uncontrollably, eventually spreading to other parts of the body. There are two main types of lung cancer - non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC), with the former constituting about 80 - 85% of lung cancers...

WCLC 2016: Discussions on Lung Cancer

IASLC 17th World Conference on Lung Cancer (WCLC) 2016 was held in Vienna, Austria from December 4-7, 2016. It is the world's largest meeting dedicated to lung cancer and other thoracic malignancies, and attracts more than 6,000 researchers, physicians, and specialists from over 100 countries. Results of various clinical drug trials that showed a reduction in risk of disease progression among...

Editor's Letter

Scanning the Future of Medical Imaging

Over the last five decades, medical imaging has repeatedly transformed medicine. Magnetic resonance imaging (MRI), dual-energy X-ray absorptiometry (DXA) and computed tomography (CT) scans have changed how physicians measure, manage, diagnose, treat, and even think about medical illnesses and conditions. Technological innovations have also made imaging faster, more precise and...

Putting Numbers into Biology: The Combination of Light Sheet Fluorescence Microscopy and Fluorescence Spectroscopy

The development of light microscopy is closely linked to requirements in the biological sciences. The invention of the optical microscope made the observation of the intricate organization of biological organisms possible for the first time. Since then, each new development in modern microscopy, including phase contrast, fluorescence and confocal microscopy, brought biologists closer to their...

Abyss Processing - Exploring the Deep in Medical Images

Medical imaging is a non-invasive method for clinicians to understand what is happening deep inside our body. The most common medical imaging techniques include MRI (Magnetic Resonance Imaging), CT (Computed Tomography), X-Ray, Ultrasound (US), Optical Coherence Tomography (OCT), etc. One of the biggest advantages of OCT [1] and US [2] over the other techniques includes its cost effectiveness...

Editor's Letter

From Home to Hospital: Digitisation of Healthcare

John Williams, a 54-year-old man with a heart condition, narrates his story: I had been having some indigestion issues since last night. I wondered if the culprit was my dinner of rib-eye steak and the two beers that I consumed along with it. I was not feeling that well so I opted to work at home. Grateful that I could access my emails through a portal, I was browsing through when I felt a sharp pain in my chest...

Microsoft with RingMD, Oneview Healthcare, Vital Images, Aruba, and Clinic to Cloud: The Ecosystem of Healthcare Solutions Providers in Asia

APBN was recently invited to experience "the Future of the Patient Journey with Microsoft & various partners" in the Marina Bay Sands Convention Centre on 28th September 2016. The atmosphere was bustling with the latest technology and innovation at the Microsoft Asia Booth where we were given the exciting opportunity to a walkthrough on how Microsoft works with its partners to provide...

Data Helps in Improving Nursing Practice, Making Better Decisions

We can't imagine a world without nurses - it will be chaos everywhere in hospitals and other medical workplaces. They work together with clinicians, facilitating treatment and delivery of patient care. They are the ones on the frontline of healthcare services, saving countless lives and helping people as much as doctors do. Nowadays, there is a lot more intention around leveraging big data to...

Launch of Asian Branch for QuintilesIMS Institute

The recently renamed QuintilesIMS Institute (previously IMS Institute for Healthcare Informatics) is a global research platform that strives to shape and drive tomorrow's healthcare industry. Its strategy is based on information and data-driven solutions, where the productive use of big data lies at the heart. Recently, more focus has been given to decision modelling...

Editor's Letter

Experience a Top Notch Medical Treatment & Hotel Stay... All in One @Farrer Park Hospital

(Through a Patient's Lens): I disembark from my car with ease, onto my wheelchair. Each individual carpark is spatially designed for ease of manoeuvring. Wheeling into Farrer Park Hospital, my spirits are immediately alleviated by the gentle floral scent wafting in the air. It reminds me of the aroma of a hotel or a posh shopping mall. The warm secular design tones of my surroundings make me comfortable and...

Providing the Personal Touch in Medical Tourism

Singapore is well known as a medical tourism centre in the region. High standards of medical care, a large pool of specialists in diverse fields and state-of-the art medical facilities are some of the factors that have been drawing patients from Asia and beyond into the country since the 1980s. This has meant brisk business for private hospitals like Mt Elizabeth and Gleneagles. However...

Hospitality Bridging Healthcare (H2H)©: Medical Tourism and Wellness

This article looks at the merging of hospitality, wellness and medical practices. Hospitality Bridging Healthcare or H2H is a natural progression, as today's savvy consumers seek timely information about their health and wellness, medical care and the quality of the service they want to experience...

Editor's Letter

Cervical Cancer is Highly Preventable. Don't Succumb to It.

"99.6% of cervical cancer can be prevented, and should be eradicated like smallpox." Dr. Chia Yin Nin, a gynaecological oncologist at Gleneagles Hospital Singapore, emphasised passionately during our interview. With relatives who have suffered from cancer diseases, Dr. Chia had always dreamed of becoming a doctor to help people and to find a cure for cancer from a young age. She is also currently...

Do Your Part to Stop Infectious Disease from Spreading: Insights from Infectious Diseases Expert-Dr. Leong Hoe Nam

Influenza viruses are divided into three types: influenza virus A, influenza virus B and influenza virus C, based on antigenic differences in their structural proteins. Influenza C viruses cause very mild infections whereas influenza A and B viruses are responsible for seasonal flu. Influenza A viruses are further classified into subtypes according to the properties of their major antigens...

Infectious Diseases in Asia Pacific: Top Five Targets for Prophylaxis Vaccines

The value of vaccines - in terms of preventing suffering, controlling outbreaks and eradicating virulent strains in the health care systems - is enormous. Unfortunately, the availability and use of prophylaxis vaccines in Asia Pacific is less than optimal for various reasons. Drawing from available literature, Quintiles' data and our experiences in helping companies develop new and better vaccines...

Editor's Letter

High-Throughput Sequencing on a Next Generation Sequencer to Identify Specific Binders from a Phage Library

In recent decades, many antibody therapeutics have been developed for the clinical treatment of cancer, auto immune diseases, and infectious diseases. Initially, these antibodies were mainly developed by the humanization of murine antibodies produced by hybridomas. Although new technologies for producing human antibodies, such as trans-chromo mice with human immunoglobulin loci and...

Antibody Solution Viscosity and Intermolecular Interactions: Considerations for Development of Highly Concentrated Formulations

In recent years, a dramatic increase in the demand for highly concentrated antibody formulations have been observed. This is due to the increasing interest in reducing burden on patients and medical professionals, which in turn is driving the shift from antibody formulations for intravenous toward subcutaneous administration. While intravenous injections should be performed by a qualified...

Display of Membrane Proteins on a Viral Envelope for Antibody Generation

Membrane proteins are a major drug target in cancer immunotherapy. Monoclonal antibodies (mAbs) against membrane proteins on target cells have attracted growing attention as a specific probe for drug delivery systems to these proteins [1, 2]. The major cancer immunotherapy target membrane proteins are thus far, cell surface receptors or adhesion molecules...

Sequence and Structural Determinants of Antigen Binding in Antibody CDR Loops

The complementary determining regions (CDRs) of antibodies play a key role in antigen recognition. The contribution of each of the six CDR loops to antigen recognition is different from each other, and even within a single CDR loop, each residue position plays a different role in antigen binding [1, 2]. Therefore, it is necessary to characterize the sequence and structural properties of...

Enhancement of the Stability of Single Chain Fv Molecules with the Amino Acid Substitutions Predicted by High-Performance Computer

A single chain variable fragment (scFv) is a kind of fusion protein keeping the function of immunoglobulin, i.e., high affinity and high specificity to an antigen. ScFv usually consists of variable regions of immunoglobulin, composed of heavy (H) and light (L) chains, and a short linker connecting the regions. Because mass-weight of scFv is smaller than that of antigen-binding fragment (Fab)...

Thermal Stability of Camelid Single Domain VHH Antibody

VHH antibody is a variable domain of camelid heavy-chain antibody and the smallest antigen binding formats that originates from a natural mammalian antibody [1, 2]. The VHH antibodies has a number of distinctive features as compared to conventional immunoglobulin G (IgG), and their excellent stability is especially emphasized in many literatures. The term "protein stability" includes...

Editor's Letter

Investing in Technology for Water Sustainability

Singapore's unique water environment requires innovative solutions, and research and development (R&D) has been the key to achieving a robust, affordable and sustainable water supply. With water demand expected to more than double by 2060, continual investment in R&D to seek more cost-effective and efficient ways of treating, recycling and supplying water is vital, especially in light of challenges such as climate change, rising energy costs, population growth and increasing urbanisation...

Water Policy Response to Water Scarcity and Future Climate Change Impacts

Water Scarcity is a multifaceted phenomenon. The most common measure of scarcity is the quantity of water that is available for consumption per capita. But water scarcity may have several other matrices by which it is measured. For example, polluted water may make it unsuitable for consumption; fluctuation of water supply (e.g., variability of precipitation) may make water planning hard to impossible; and inadequate infrastructure (e.g., lack of storage, deteriorated conveyance system) may lead to losses of water resources that otherwise could be consumed...

Recirculation Aquaculture Systems (RAS): An Opportunity for the SE Asian Aquaculture Industry

A recent study by the World Bank stated that aquaculture is a major sector that is still expanding and receiving considerable attention as a way to fill the growing seafood supply gap which is estimated to have increased to 30 million tonnes by 2030. However, aquaculture cannot be practised everywhere; it requires a unique set of natural, social and economic resources, which must be utilised wisely for the development of the sector to be sustainable...

Editor's Letter

Bone Healing from Within

People are living longer than ever before because of advancements in medical technology and the public's increased understanding of how to live healthier. The United Nations estimates that by 2050, at least two in every five persons will be aged 60 years or older. East Asian countries are leading this segment, followed by Southeast Asia and South Asia. And, as economically advanced countries like...

How Technology Helps in Care Coordination: Telehealth?

What is Philips' future plan and commitment in terms of digital health in Singapore? Philips' vision is to improve the lives of three billion people a year by 2025. We understand that Asia's healthcare industry is facing several challenges and pressures today, including an ageing population, rising chronic diseases and lack of hospital beds. We believe that technology and digital health will play a fundamental role in...

Soft Wearable Machines for Robot-Assisted Rehabilitation

Stroke is one of the leading causes of disability, whereby 15 million people worldwide suffer a stroke each year and nearly a third of them are left permanently disabled [1]. Post-stroke neurological impairment often leads to paralysis of one side of the patient's body, which can affect his/her ability to perform basic activities of daily living, such as grasping household items [2]. This inability to...

Technology Can Help Patients Find Doctors and Share Medical Data

The healthcare industry has proven to be one of the most resistant among verticals to adopting technology as far as discovery and delivery of healthcare services is concerned. In the last ten years, there had been no significant change in the way people experienced healthcare, despite that science around developing drugs had gotten better, and there were more hospitals and clinics being built...

Seizing Opportunity in Asia-Pacific's Complex and Rapidly Changing Medical Device Market

Asia-Pacific is the world's fastest growing biopharmaceutical market - a diverse "market of markets" that holds great potential because of its expanding economies, huge and growing population, and vast number of patients with poorly met or unmet medical needs. The region's potential for medical device development and commercialisation is no exception. But even more so than in biopharma development...

How Logistics Technology Can Treat Tomorrow's Life Sciences & Healthcare Complications

The life sciences & healthcare (LSH) sector is undergoing rapid changes. Today, the global pharmaceuticals market is worth US$300 billion a year, a figure expected to rise to US$400 billion within three years [1]. The medical devices market is going strong as well - its value will reach a projected US$398 billion by 2017 [2].As the LSH industry reaches new heights, it also has to deal with new challenges...

Editor's Letter

A Glimpse into Healthcare Policies: How Cancer Control and Prevention Programmes Have Evolved Across Asia:

Understanding Healthcare Policies in the Philippines: Cancer Care

We had an interview with Assistant Secretary of Health from the Philippines, Dr. Gerardo V. Bayugo, at the Healthcare Forum: War on Cancer 2016... The Department of Health (DOH) utilises various approaches in promoting the different health programs and policies within the country. In crafting policies, we ensure that relevant medical specialty societies, non-government organisations...

Healthcare Systems and Health Policies in Thailand: Cancer Care

As one of the speakers for keynote panel discussion of The Price of Policy at Healthcare Forum: War on Cancer, Dr. Pannet Pangputhipong shared about the healthcare systems and cancer control policies in Thailand. Dr. Pangputhipong has been assigned to supervise Thailand's National Cancer Institute and Regional Cancer Hospitals which responsible for Cancer Control, Cancer Care and Policy Advocacy...

Cancer Care and Control in Taiwan: An Interview with Dr. Shu-Ti Chiou

Taiwan set a good example by having efficient cancer care & control programmes to cope with the growing cancer burden in the country. We invited Dr. Chiou Shu-Ti, to share insights on how Taiwan government manages cancer care & control effectively...

An Interview with Professor Myint Han: Healthcare in Myanmar

There are 51 million people in Myanmar, and 70% of them live in rural areas. It is extremely important that we act fast to improve accessibility and affordability of healthcare services. In the past 5 years, we have increased national healthcare budget for cancer control to address the issues, specifically around prevention...

Editor's Letter

Fighting Cancer with Immunotherapy

Every year, on the first weekend of June, tens of thousands of cancer specialists will gather in Chicago, Illinois to listen and share the latest advances in cancer management. In year 2015, the buzzword that kept resounding in the colossal halls was "immunotherapy"...

21st Century Cancer Warfare: A Glimpse into the Operations of a Modern Radiotherapy Unit

Modern warfare has become highly complex over the past century, driven by advancements in strategies and technology as well as nations' incessant drive to stay ahead of the game. In a similar fashion, the war against cancer has reached new heights in the 21st century. However, unlike the zero-sum game in human conflict, the cumulative pool of scientific discovery coupled with...

Is Colorectal Carcinomas due to 'Bad Luck' or Is It Preventable?

Colorectal Carcinomas (CRC) is the leading cancer in the developed world. In Singapore, it is the most frequent cancer for men and women combined and the second leading cause of cancer mortality. [1] A recent statistical study on the etiology of cancer has attributed cancer incidence to lifetime tissue specific progenitor or stem cell divisions...

Asian Point of View on Cancer

Cancer is an ancient disease, first described in humans in the Egyptian Edwin Smith Papyrus dated to the 17th century BCE [1]. Consequently, the research of cancer has been conducted for thousands of years with the earliest theory of cancer articulated by Hippocrates...

Improving Overall Survival in Hepatocellular Carcinoma through a Multi-Disciplinary Approach: Intra-Tumoral Heterogeneity, Immunology and the Promise of Better Outcomes

Hepatocellular carcinoma (HCC) is the 6th most common cancer in the world and is diagnosed in more than a million new patients a year. It is however the 2nd most important cause of cancer death [1] and the 3rd most important cancer in Asia [2-4]. Surgery is potentially curative in early HCC which...

Cancer of the Cervix - Can It be Prevented?

CANCER - a word and disease that strikes pain and fear in everyone and sounds the death knell for those diagnosed with it. From time immemorial, doctors and scientists had tried to find the causes and cures for cancer. The strive towards these ends are still on-going and to date...

Editor's Letter

Novel Topical Mesenchymal Stem Cell Transplant Paradigm to Treat Organ Diseases

Somatic stem cells attract great scientific and public interest and have real appeal for tissue repair and regeneration. Hematopoietic cells and mesenchymal stem cells are the two major adult stem cells. Mesenchymal Stem Cells (MSCs) were initially found in bone marrow by Friedenstein and his colleagues. Subsequent work showed...

The Potential of Stem Cell Therapy for Brain Repair and Regeneration Following Neurotrauma

Traumatic brain injury (TBI) is a major health problem worldwide. Despite improving survival rate after TBI, currently, there is no effective treatment to improve neural structural repair and functional recovery of TBI survivors. Neural regeneration either through stimulating endogenous neural stem cells or through stem cell transplantation has gained...

Liver Regeneration Enables Miracle of Liver Transplantation

The liver is a unique organ due to its ability to regenerate after injury or partial removal. This special quality of the liver has been described as far back in history as ancient Greek mythology, in the story of Prometheus. [1] Prometheus, whose name means "Forethinker", was a powerful Titan, known as the supreme trickster and god of fire. He has been credited...

Editor's Letter

The Human Biomedical Research Act: Overview and International Comparisons

Regulatory regimes for research such as the 'Common Rule' (US federal regulations governing research involving human subjects) and the CIOMS Ethical Guidelines for Biomedical Research are currently being revised, in view of shifts and innovation in research activities and ethics, with the goals of enhancing respect for research subjects and improving research efficiency. In line with these developments...

Tissue banking in Singapore - An Evolving Enterprise

Biobanking of residual human biological materials (HBMs), usually obtained from surgeries, is crucial in biomedical research for the advancement of science and public health. [1] Research results obtained from studies using HBMs improve drug discovery, clinical management and current treatment...

After Ebola, Social Justice as a Base for a Biobanking Governance Framework

About two years ago, the outbreak of Ebola in West Africa has generated a great number and variety of biological samples. Such samples constitute a valuable, non-renewable resource, and offer a unique opportunity to increase our knowledge of the Ebola virus and its pathogenesis. However, there is no generally agreed plan on how to manage these specimens equitably. This paper argues...

Community Engagement for Biobanking Research: Perspectives from Africa

Recent trends in research governance have seen a review of the role that communities should play, particularly in emerging and innovative research. International guidelines from the Council for International Organisation of Medical Science, the Declaration of Helsinki, the Nuffield Council on Bioethics and the National Institute of Allergy and Infectious Diseases all stress the importance of early community engagement to ascertain their views on the research and to develop...

Editor's Letter

Current State of Microalgae-derived Biofuels and Bioproducts Research in South Korea: Outcome and Future Direction of Advanced Biomass R&D Center (ABC)

Critical needs of alternative energy have coerced the South Korean government to actively invest in biomass-based energy development. One such example is to launch Advanced Biomass R&D Center (ABC), which will receive approximately USD $100 million from Korean Ministry of Science, ICT and Future Planning (MSIP) for duration of nine years. More than 100 experts from various research fields including...

Medicinal Bioconvergence Research Center: An Integrated Research Platform for Novel Target and Lead Discovery

In 2010, the Korean Ministry of Education, Science and Technology (MEST) launched the Global Frontier Project, targeted at solving global challenges in major R&D areas. The Medicinal Bioconvergence Research Center (Biocon) was initiated as one of the three projects with the aim to resolve difficulties during the development of novel drug discovery...

BioNano Health Guard Research Center

Global frontier program is Korean government representative research program funded by the Ministry of Science, ICT and Future Planning (MSIP). The vision of this program is the development of world-class core technologies and the creation of an economic growth. Global frontier program started from 2010 and currently 10 research centers are onto vigorous research work...

Bio-Synergy Research Center: Knowledge-based Systems Biology Platform for Natural Product Engineering

According to the World Population Ageing 2013 Report by the United Nations (UN), population ageing is already a global phenomenon. UN further emphasized the major social and economic consequences, which includes fiscal pressures on social healthcare systems. To cope with this situation, the paradigm of healthcare is shifting from disease 'treatment' to 'prevention'. The convergence of information technology (IT) and biotechnology (BT) will...

Brief Introduction to the Project on Systems Metabolic Engineering for Biorefineries

Due to the increasing concerns on climate change, resource limitations and sustainability issues, and to reduce the dependence on fossil resources in petrochemical industry, there have been interests in developing bio-based chemical industry through establishing successful bio-refineries. Microorganisms, corresponding to the chemical plant converting a raw material to a product of interest...

Editor's Letter

COP21- A Health, Technology, Energy, Transportation Agreement

Conference of Parties (COP) 21 also known as the 2015 Paris Climate Conference shall be the first UN negotiation with the aim to achieve legally binding and universal agreement on climate, to reduce global warming by 2oC, and 5% reduction in greenhouse gases. COP21 will be held at Le Bourget...

Prelude COP21

Editor's Letter

Smog Free Tower: The Huge Hoover in the City

I magine waking up in the morning and you look out of the window, it is a clear blue sky. When was the last time you breathe in clean air?...

A New Look into Toxicology Risk Assessement and Environmental Safety. Systems Biology Verification – The Toxicology Risk Assessment Network Verification Challenge

Julia Hoeng is Manager of Systems Toxicology at PMI Research & Development where she leads the Systems Biology Program, covering a portfolio of projects in vitro, in vivo and in silico research for product testing...

Effective remedies to the Southeast Asia Transboundary Haze: What’s burning?

It's the time of the year again when we start stocking up on N95 masks. Yes – the haze is back. Southeast Asia is no stranger to the haze particularly Singapore, Malaysia and Indonesia. Transboundary haze has been a serious problem since the 1970s...

The Haze Blanket on your Lungs, the Environment and the Costs.

There are a few elements on this planet that are vital for the existence of mankind and animals, including some species which are at the brink of extinction...

Editor's Letter

ESRI: Amplifying Spatial Awareness via GIS

Tech which brings Healthcare Management, Preventative & Predictive Measures under the same Cloud. Esri is the world leader in geographic information system (GIS) technology. GIS is a powerful spatial analytic tool for hospitals and health systems in areas...

iDA: When it is not just about size, you gotta' be Smart, too!

The mission of the Infocomm Development Authority of Singapore (IDA) is to develop information technology and telecommunications within Singapore with a view to serve citizens of all ages and companies of all sizes.

MHC Asia: Chew on It!

How Singapore-based Health Informatics Company crunches big-data to uncover your company's health

Dassault Systèmes: Digital tool when well-used, it is Passion

With a soaring global population, vast numbers of people are facing living in cities that are built for much smaller populations with very different needs. This puts our environment at risk....

Carving the Digital Route to Wellness

Transmit your blood sugar results from a digital glucose monitor. Snap a photo of your breakfast to capture calorie intake. Upload your most recent weight reading and record the number of steps walked. Once completed...

Big Data, Bigger Disease Management and Current preparations to manage the Future Health of Singaporeans

Continuous data collection for chronic illness management is crucial to deliver personalized care for patients. In the era of globalization, patients still do not have the right tools to collect and share their physiological information on a frequent, real time basis...

A Conversation with Mr Arun Puri

Arun Puri is currently working as Lead, Web Systems at Quantum Inventions Pte Ltd. He has 15 year experience working in start-ups, or start-up type organisations. He has experience in both sides of the aisle with respect to data; consuming data to create applications and mashups during his earlier ventures...

Health Solutions using Purview by Extreme Networks Health Solutions

Morbidity is an increasing public health concern in the world, and hospitals are depending on technology intelligence from real-time healthcare applications and devices to improve hospital workflows, safety and costings. At HIMSS AsiaPac15 held in Singapore, Mr Bob Zemke, Director of Healthcare Solutions....

Big Data in Clinical Research Sector.

Mr Naz Haji holds a dual role as the Head of India, and SVP and CIO Asia. He joined Quintiles in 2006 as Vice President, Global IT in Research Triangle Park, North Carolina, leading Global Infrastructure and Operations....

Editor's Letter

The ASEAN Economic Community — Challenges and Opportunities for Healthcare Companies

Tapping on ASEAN'S Healthcare Opportunities through Singapore by Dr Derrick Tan

The Association of Southeast Asian Nations (ASEAN) is a geo-political and economic organisation comprising of Singapore, Indonesia, Malaysia, Thailand, the Philippines, Brunei, Myanmar, Cambodia, Laos and Vietnam. Established in 1967...

ASEAN - The New Playing Field for Global Medical Device Companies by Cecelia Zhou

In the last decade, many global medical device companies have invested heavily in the emerging markets of China and India. These companies have subsequently benefited ...

The Burden of Great Potential: the ASEAN Economic Community & Biopharmaceuticals by Dr Ross Horsburgh

The story of biopharmaceutical research and development in the Association of Southeast Asian Nations (ASEAN) is one of the great, but as-yet unfulfilled potential. Over the past 30 years, the ASEAN region has evolved from a high-risk frontier of research...

Impact of the ASEAN Economic Community on the Region's Healthcare Market by Dr Umapathy Panyala

The formation of the ASEAN Economic Community or AEC is a major initiative of the Association of Southeast Asian Nations (ASEAN). It seeks to integrate Southeast Asia's diverse economies into a single market and production base...

Editor's Letter

Are BIOFUELS the next Energy-Giant and Are More Renewable Energy Sources Required to Turn those Bureaucratic Cogwheels?

Biogas beats Bioethanol by Prof. Wolfgang Bauer

The purpose of all biofuel production is to harvest the energy provided by solar radiation and use it to displace fossil fuels and their associated pollution and greenhouse gas load. Liquid or gaseous biofuels can be generated from organic waste...

Molecular Marvel: A Novel Catalyst greases the wheels of Biofuel production by Gabrielle Bauer

Depending on how many years separate you from your last chemistry class, you may or may not remember the definition of a catalyst; a compound that facilitates a chemical reaction without being consumed by the reaction...

Editor's Letter

MERS-CoV: Middle East Respiratory Syndrome Coronavirus The new zoonotic viral pneumonia which appears to originate from camels in the Middle East, also known as Camel Flu. The first animal-to-human case was reported in Saudi Arabia in 2012. This infectious disease has spread across many countries and nationalities including Korea, United States, Thailand, etc.

An interview with delegate Professor Jiang ShiBo

Professor Jiang received his Ph.D. at the Furth Military Medical University and postdoctoral training in Rockefeller University. From 1990 to 2010, he was appointed as the Head of Laboratory at the Lindsley F. Kimball Research Institute of the New York Blood Center. In 2010, Jiang was awarded as a scholar "One-Thousand- Talents", and he later joined Shanghai Medical School, Fudan University.

An interview with Dr. Michael Whitt

Dr. Whitt is a Professor and Chair in the Department of Microbiology, Immunology and Biochemistry at The University of Tennessee Health Science Center (UTHSC) in Memphis, Tennessee. His expertise is molecular virology, with a particular focus on the cell biology of virus entry, replication and assembly of - negative-strand RNA viruses.

Shantou University Medical College (SUMC) made the first debut as the Chaozhou Obstetrics Training School, 1924. When Shantou University was established in 1981 by Mr Lee Ka-shing, the medical school was founded as the medical college, and now it is known as SUMC. The medical school offers two medical programmes; English-taught and Mandarin MBBS programme. The medical programmes are approved by the Ministry of Education in China, and elite medical students enjoy full tuition grants.

A conversation with Dean Professor Bian Junhui

Dr. Junhui Bian graduated from the 8-year medical program at Peking Union Medical College in 1987 and worked as a researcher at Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences. In 1988, he was admitted into the Ph.D program of University of Maryland School of Medicine on a full scholarship and was awarded the Ph.D degree in Biochemistry in 1993. Subsequently, he served as a postdoctoral fellow, assistant professor, associate professor and professor at Oklahoma Medical Research Foundation, Parke- Davis Pharmaceutical Research (A Warner-Lambert Company, now Pfizer), Abilene Christian University, and Shantou University Medical College respectively.

Editor's Letter

Generating and supporting start-up biotech companies

Partnering For Success -Mr Johnson Chen Founder and Managing Director Clearbridge BioMedics

ClearCell FX System: It is well known that the healthcare start-up journey is particularly difficult and challenging. This is because biotech entrepreneurs face tougher challenges such as long product development cycles, stringent regulatory hurdles, time-consuming clinical trials, need for multidisciplinary R&D teams and significant capital requirements. For any medtech company, establishing the right partnership is not only useful but vital to achieve success.

Endofotonics: From Technology Innovation to Start-Up Venture by Associate Professor Hwang Zhi-Wei, Professor Ho Khek-Yu

The journey from innovation to commercialization is filled with relentless challenges. It is even more so for bootstrapped academia-based innovation ventures. Hence, the unveiling of the start-up medical technology company, Endofotonics Pte. Ltd. in Singapore on 26th Aug 2013 was more than just a seminal moment for its founders, Associate Professor Hwang Zhi-Wei, and Professor Ho Khek-Yu, both from the National University of Singapore.

Generating the Pipeline of Biotech Start-Ups Participants of the LLP program in 2015 by Ms Susan Kheng Associate Director, [email protected], NUS Industry Liaison Office (ILO)

In order to help move research out of the labs and into the commercial marketplace, NUS Enterprise has taken cues from a successful commercialization program in the US, known as "I-Corps" by the National Science Foundation (NSF). "The National Science Foundation (NSF) announced the Innovation Corps (I-Corps) - a program to take the most promising research projects in American university laboratories and turn them into startups.."

AYOXXA with A Clear Vision towards Ophthalmology by Dr. Marion Lammertz, Marketing Manager Communications Global Commercial Operations; AYOXXA Biosystems GmbH

AYOXXA is a spin-off from the National University of Singapore (NUS) with operations in Cologne, Germany and Singapore. It has invented a unique bead-based protein multiplexing technology which yields about 10.000-fold more data-points than a standard ELISA. It allows simultaneous detection of multiple analytes in pg/mL concentrations, requiring very little sample volumes (3µL). Development of the system was spearheaded by Dr. Dieter Trau Associate Professor at the Department of Biomedical Engineering at National University of Singapore (NUS) in 2010.

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